mjl1717
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What does superoxide dismutase do and what does myeloperoxidase do?
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| Quinn
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Superoxide dismutase converts superoxide to peroxide.
MPO or myeloperoxidase system is main system by which cells detoxify oxy radicals...i.e. it is the oxygen dependent process of destruction in mac's and neutrophils.
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| rida
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Involved in phagocytosis of the bacteria.
When bacteria encountered :arrow: phagocytosis occurs :arrow: NADPH oxidase converts molecular Oxygen to superoxide :arrow: superoxide mutase converts superoxide to hydrogen peroxide :arrow: peroxide converted to hypochlorous acid (bleach), however only in prsence of myeloperoxidase and chlorine :arrow: kills bacteria.
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| mash
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superoxide dismutase converts superoxide to H2O2 + O2
myeloperoxidase
H2O2 + Cl- ________________ HOCl(free radical ) n it kills bacteria
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| mjl1717
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Good- just to complete it catalase breaks down H2O2 to water and O2
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| asmi
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high yeild topic :idea:
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| Bela
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I agree. Goljan gave it too much importance. Well, so what's the deal with bacteria such as staph or pseudomona? Why can they kill a young pt? 
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| rida
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Because they have catalase, which breaks down hydrogen peroxide so this system messes up and can't kill those bacteria.
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| Bela
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Good Rida 
MJL, when you talk about H2O2 being broken down by catalase, I have a question regarding that.
Now, I know that in PMNs/Monocytes, they have the myeloperoxidase system, so H202 is broken down by MPO, therefore killing bacteria.
In all cells except RBCs, I thought that H202 can be broken down by catalase, giving H20. So H202 can take 2 routes, depending if the cell is a specialized one (PMN/monocyte) or if it's just a normal cell. Is this true????
In RBC, I thought O2 spontaneously goes to H202...I mean it doesn't use NADPH oxidase....and then H202 :arrow: H20 via glutathione peroxidase.
Am I correct or not? :?
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| Quinn
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that's right forgot the O2 for SOD. What is the relationship to ALS?
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