rubensssss
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Calculate the total amount of cortisol, filtered in the kidney per hour under the following condition:
GFR=120ml/min, Total cortisol=15micrograms/100ml, free/ total cortisol=5%
A-108 micrograms
B-54 micrograms
C-1080 micrograms
D-540 micrograms
E-27 micrograms
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Ruben sssss
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| rida
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E.....
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| mani
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i think its A.
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| rubensssss
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Approx 95% of total cortisol is transported by proteins: about 80% is bound to a specific coticosteroid binding globulin, transcortin and another 25% is transported by albumin, leaving a fraction of 5% free.Sice cortisil binding proteins have relatively high molecular weights, onlty the free fraction is filtered by the kidney. FRom the data given, hte plasma concentration of freecortisol is 0.75 micrograms/100ml, and the glomerular filtration rate is 7200ml/hr, thereford the filtered amount of cortisol is 72 X 0.75micrograms= 54 micrograms.
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