mjl1717
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Only about 30,000 people in the US per year get this disease-its associated with decrease Zn and Cu binding at superoxide dismutase on chromosome 21-resulting in oxygen free radical destruction of motor neurons-Which is it?
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| Alina T
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ALSSSSSSSSSSS
thats how a very good friend of mine calls me 
hey, smitha!!
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| mjl1717
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Very Good-so its part of a nickname--Today I hear there are 2 forms one is the bulbar form,I dont know the other?
Also slurred speech is probably the beginning of the end. [The prognosis is only 1 to 3 years
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| Alina T
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i havent read anything about the 2 forms, but i guess it could be a spinal one and a bulbar one, if reffering to the motor neurons that it affects. the bulbar one will be worse, if we think about the respiratory centers that it will affect earlier.....
just guessing here at this late hour (its almost 1 am here......)
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| jijibibi
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There are three types of ALS. The most common type is called sporadic ALS. This type of ALS is not hereditary and accounts for 90% of ALS cases. Familial ALS is hereditary, is passed on by a dominant gene and accounts for nearly 10% of ALS cases. The third type of ALS is called Guamian and is related to the high incidence of ALS on the island nation of Guam.
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| jijibibi
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Most ALS patients first notice muscle weakness in either the arms or the legs (32 percent in the arms and 36 percent in the legs.) This is called limb-onset ALS. Approximately 25% of ALS patients have difficulty speaking as their first symptom. This is called bulbar ALS because it involves the corticobulbar area of the brainstem. ALS is a very variable disease, and there are also cases affecting breathing first, without any other symptoms. Approximately 7 percent have difficulty breathing (dyspnea) as their first symptom.
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| jijibibi
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Bulbar ALS is the type of ALS where speaking and swallowing difficulties are the first symptoms. Many patients with bulbar ALS are unable to speak or eat but are able to walk and write. Bulbar-onset ALS patients generally have a faster disease progression than do limb-onset patients. Limb-onset patients eventually develop bulbar symptoms as their disease progresses.
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| mjl1717
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Thank You
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