ngaybinhyen wrote:
I can't find any information re: Diastolic dysfunction in HT
Here are a few Rx strategies
1. Systolic heart failure ----> Primary outcome: CV events
- ACEI (CONSENSUS, SAVE)
- ARB (Val-HeFT, CHARM)
- β-Blocker (MERIT-HF, COMET)
- Aldosterone antagonist (RALES)
2. CV disease ----> Primary outcome: CV events
- ACEI (HOPE, EUROPA)
3. Left ventricular hypertrophy by electrocardiography ---> Primary outcome: Stroke
- ARB (LIFE)
DrAlex, Can you post the whole Q?
Risk Factors and Causes
Any condition or process that leads to stiffening of the left ventricle can lead to diastolic dysfunction.
Some causes of left ventricular stiffening include:
- high blood pressure (i.e. hypertension, where, as a result of left ventricular muscle hypertrophy to deal with the high pressure, the left ventricle has become stiff)
- aortic stenosis of any cause (here as with hypertension, the ventricular muscle has hypertrophied and thence become stiff, as a result of the increased pressure load placed on it by the stenosis)
- scarred heart muscle (e.g. occurring after a heart attack) (scars are relatively stiff)
- diabetes (stiffening occurs presumably as a result of glycosylation of heart muscle)
- severe systolic dysfunction that has led to ventricular dilation (i.e when the ventricle has been stretched to a certain point, any further attempt to stretch it more, as by blood trying to enter it from the left atrium, meets with increased resistance - it has become stiff
- reversible stiffening as can occur during periods of cardiac ischemia
Reference : http://en.wikipedia.org/wiki/Diastolic_dysfunctio...
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| ngaybinhyen
Forum Guru
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Eagle, How do you use this piece of information to answer the Q?
Just to be clear, I'm aware of diastology in HT. I certainly don't have enough knowledge to show on this forum. My point is I could not find HT and diastolic dysfunction as an isolated entity in which people conduct studies to seek for an appropriate therapy in favor of improving outcome.
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| DrAlex_76
Forum Guru
Topics: 120
Posts: 410
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HTN -------> diastolic dysfunction ----------> Treat with " new beta blocker " atenolol because :
decrease the afterload which every " heart " loves
decrease the rate which improves the " tank " filling
answer is B
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| nightflight1945
banned
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Nice question , alex!
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| altabban
Forum Newbie
Topics: 2
Posts: 29
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beta blocker beta blocker beta blocker, whenever the heart is involved in HTN pts, give beta blockers..
it will be reasonable of coure to add ACEI to decrease the stress on the left ventricle.
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