Alina T
Forum Elite
Topics: 17
Posts: 388
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Wolff-Chaikoff effect is due to an excessive I intake, for example in patients cronically taking amiodarone. the excess of intracellular I will inhibit the expression of TPO --> I isn't combined with TG anymore --> decrease in T4 and T3 :arrow: hypothyroidism.
eventually, there will be an "escape phenomenon", due to inhibition of the symporter which introduces Iodine into the cell :arrow: decrease of i.c. I :arrow: removes the block in TPO expression :arrow: increase of T4 and T3. (this happens after about 2 weeks of block).
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| fried water
Forum Junior
Topics: 4
Posts: 57
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simple explanation!:
excess iodide intake inhibits the iodide pump (which is responsible for intake of iodide into thyroid gland).. thus it inhibits thyroid hormone synthesis in a way. This is Wolf-C phenomenon.
But if you continue high doses of iodide over weeks, thyroid escape occur and patient gets hyperthyroidism.
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