mdwannabe
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What is the initial step, in alternative pathway? Where do those C3b's come from in sterile person? :-)
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| rida
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Complement binding directly on polysaccharides of bacteria is the initial step. I believe C3b comes from spontaneous degradation of C3, but not exactly sure.
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| mdwannabe
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Yep... "it is called a "tick-over" hydrplysis of C3 and formation of C3i which binds Factor B, which then is cleaved by Fac D, to Bb... so you got now C3iBb... with same function as C3bBb.
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"Life not lived for others, is not worth living" Uncle Einstein
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