tompat
Forum Elite
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hello every one,
i just wanted to know within how many days kidney starts compensating for metabolic abnormalities originated from else where?
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| SILVER
DoWhatYouGotToDo!
Topics: 45
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wouldn't it depend on the severity of metabolic derangement and the functional status of the kidney itself at that time? i don't think there is any standard time frame.
plz correct me if i'm wrong.
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| tompat
Forum Elite
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thanks for the reply.
please do not consider anything not given in the question stem. in this condition we assume kidneys are normal. to make it simple, lets say we have respiratory acidosis because of acute exacerbation of COPD. again please consider here that there were no metabolic abnormalities in this pt few hours back and kidneys were functioning normally .
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| tompat
Forum Elite
Topics: 39
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i remember from physio video lectures that renal compensation takes time, i think probably 5-7 days to see the effect. but i m not very sure about it.
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| SILVER
DoWhatYouGotToDo!
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i'll have to read up on it too.
btw, thanks for this kick-start, i've been avoiding acid-base balance for so many days now! 
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| SILVER
DoWhatYouGotToDo!
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In acute respiratory acidosis, compensation occurs in 2 steps. The initial response is cellular buffering that occurs over minutes to hours. Cellular buffering elevates plasma bicarbonate (HCO3-) only slightly, approximately 1 mEq/L for each 10-mm Hg increase in PaCO2. The second step is renal compensation that occurs over 3-5 days.
http://www.emedicine.com/med/TOPIC2008.HTM
this is what i could find from eMedicine.
hope this helps
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Stop telling God how big your storm is. Instead, tell your storm how big your God is.
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| SILVER
DoWhatYouGotToDo!
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Renal compensation for sustained hypercapnia begins in 6-12 hours, but 3-5 days pass before maximal compensation occurs.
This is from a more recent eMed. article.
http://www.emedicine.com/PED/topic16.htm
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| tompat
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Topics: 39
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thanks a lot silver
all the best
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