clar697
Forum Guru
Topics: 190
Posts: 199
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A 31-year-old man with AIDS is receiving highly active antiretroviral therapy (HAART). Labs show significant myelosuppression and a decreased plasma HIV-mRNA burden. To counteract this toxicity (rather than modify his antiretroviral therapy), he begins treatment with hematopoietic growth factor. Thirty minutes later, he develops dyspnea, severe muscle pain, vomiting, and sinus tachycardia; his blood pressure is 80/40mmHg. Which of the following hematopoietic growth factors most likely caused these new findings?
A) Erythropoietn
B) Filgrastim (G-CSF)
C) Platelet derived growth factor
D) Sargramostim (GM-CSF)
E) Thrombopoietin
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| tiz_83
Forum Newbie
Topics: 2
Posts: 16
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Is it D..GM-CSF?
GM-CSF leads to increased eosinophils which causes anaphylaxis.
"In the presence of ATRA and granulocyte colony-stimulating factor (G-CSF), the cells showed polymorphonuclear neutrophil differentiation accompanied by expression of surface CD11b, CD15, CD10, positive activity for neutrophil alkaline phosphatase (NAP), and NAP mRNA expression. In cultures with ATRA and granulocyte-macrophage colony-stimulating factor (GM-CSF), IL (interleukin)-3, or IL-5, HT93 showed remarkable eosinophil maturation at day 8 as determined by luxol fast blue staining, in addition to expression of eosinophil peroxidase and major basic protein."
The para above basically says that its GM-CSF and not G-CSF which helps in eosinophil maturation
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