clar697
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During a meal, the vagus nerve stimulates secretion of acetylcholine, which stimulates the stomach to secrete HCl in a second-messenger pathway derived directly from the membrane phospholipids. Which of the following second messengers is involved?
A) cAMP
B) cGMP
C) Choline
D) G protein
E) Inositol 1,4,5-triphosphate
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| hitesh
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E) Inositol 1,4,5-triphosphate
It acts on M3 receptors.. which are the Gq type..
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| gray
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is H2 responsible for increase acid secretion.
so is this Gs rather than Gq
Gs incr adenyl cyclase incr cAMP
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| GoodGirl
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Answer is E.
The question stem give the answer itself '' derived from membrane phospholipids'' --->
PIP 2 -> IP 3 + DAG
M1(Gq) receptor on gastric parietal cells
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| shock
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ip3
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| winnera
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