clar697
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A 3-year-old girl is brought to the emergency department unconscious after ingesting and unknown quantity of ethanol. Her serum glucose concentration is 30mg/dL. Through which of the following mechanisms are the products of alcohol metabolism contributing to the hypoglycemia?
A) Increasing the conversion of pyruvate to oxaloacetate
B) Increasing the formation of pyruvate from acetyl CoA
C) Increasing the reduction of pyruvate to lactate
D) Inhibiting pyruvate dehydrogenase
E) Inhibiting the formation of pyruvate from alanine
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| Karime
Forum Guru
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C) Increasing the reduction of pyruvate to lactate:
"The abundance of NADH (from alcohol metabolism), favors the reduction of pyruvate to lactate (an intermediate in the synthesis of glucose by gluconeogenesis). The ethanol mediated increase in NADH causes the intermediates of gluconeogenesis (lactate, osalacetate...etc) to be diverted into alternate reaction path ways resulting in the decrease synthesis of glucose" (Lippincott's Bioch review)
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| DRFP
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Alcoholics = trouble making Glucose ( Goljan) NADH:NAD+ ratio increased
pyruvate is key for Acetyl CoA and Oxaloacetate in Citric Acid cycle
So the answer is
c: increasing the reduction of pyruvate to lactate.
you see beta hydroxybutin increased NADH prevents glycolysis shunts pyruvate and oxaloacetate to lactate and malate. You see Ketone bodies
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| cooolguy
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i concur! C
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