clar697
Forum Guru
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Embryonic chondrogenesis requires the formation of mesenchymal condensations at the sites of future cartilage. During this developmental step, cAMP concentrations in the cells comprising the condensation increase significantly. Treatment with a membrane-permeable form of cAMP (eg dibutyryl cAMP ) allows individual mesenchymal cells to differentiate into chondrocytes without first forming these condensations. Inhibition of which of the following enzymes would most directly inhibit dibutyryl cAMP-mediated induction of chondrogenesis from mesenchyme?
A) Guanylyl cyclase
B) Phosphodiesterase
C) Proteasome
D) Protein kinase A
E) Tyrosine kinase
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| Gourdon
Forum Senior
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D
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| Karime
Forum Guru
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I'd also go for D
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Eterea ……..“Hoc in loco mors succurrere vivis gaudet”……("In this place death comes joyfully to the aid of the living" )
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| shock
Forum Newbie
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protein kinase a
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| cooolguy
Forum Newbie
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can someone please explain this?
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| Karime
Forum Guru
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Posts: 1,270
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Let my try:
think about G protein signals.......cAMP acts as a 2nd messenger activator of PK-A
pro.JPG (14 KB)
If dibutyryl cAMP is an analog of cAMP.......and if we inhibit PK-A we are actually inhibit the
dibutyryl cAMP-mediated induction of chondrogenesis.
correct me please if I'm wrong
Attached Files:
pro.JPG (14 KB, 15 downloads)
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Eterea ……..“Hoc in loco mors succurrere vivis gaudet”……("In this place death comes joyfully to the aid of the living" )
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| winnera
Forum Senior
Topics: 21
Posts: 86
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i also answered d
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| alirizvi
Forum Elite
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Posts: 372
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PDE breaks camp --> amp .. so cant activate protein kinase A
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We are what we repeatedly do. Excellence, therefore, is not an act, but a habit. - Aristotle.
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