mash
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If an X-linked recessive disorder affects approximately 1/1,000,000 females (all homozygotes) in a population, what is the expected frequency of affected males in the population?
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| beta
Forum Newbie
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affected males in this population
=1/ 1000
what is the answer.... :?:
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| mash
Forum Fanatic
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yeah, its 1/1000...........
can u explain, why?
coz acc to HW principle, q2=1/1000,000 which means q = 1/1000
so,female heterozygote frequency wud be 2pq = 2*1*1/1000=1/500
then how do we calculate frequency of affected males?
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I hear and I forget. I see and I remember. I do and I understand.
--Confucius
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| piter
Forum Elite
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maybe coz male have one X, so probability is 2 time lower - 1/1000...?
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| beta
Forum Newbie
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-for X-linked recessive disease- the gene frequency (q) = the frequency among males.
so when q^2 =1/ 1000,000
then q= 1/1000
i hope this helps....
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| mash
Forum Fanatic
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alright, i got it.
thanx!
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I hear and I forget. I see and I remember. I do and I understand.
--Confucius
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