NBME F5 S4 enzyme misfolding

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NBME F5 S4 enzyme misfolding

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6 Posts

clar697
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07/10/08 - 06:47 AM

A biosynthetic error in reading the genetic code gives rise to an enzyme that folds in an abnormal manner. Which of the following is most likely to happen to this enzyme?

A) Denaturation and refolding
B) Faster degradation
C) Inactivation by phosphorylation
D) Transportation out of the cell via the Golgi complex

SpeaksSoftly
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07/16/08 - 08:30 PM

C? I have no idea.

maoudoody
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07/29/08 - 10:09 AM

b

transmitted to proteasomes bound to ubiquitin where the protein is degraded to polypeptide chains

cool02
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08/06/08 - 01:10 PM

hi..
i feel D.
as there is no proof reading in translation so whatever error has takken place protein
synth will continue along its normal course.
for ex. in cystic fibrosis there is def in ctfr transmemb pr.

spinal shock
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08/26/08 - 05:38 PM

b, d occurs normally in lysosomal protiens

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brainstem
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10/11/08 - 07:01 AM

B - Tagged with ubiquitin & digested in proteasomes.

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