USMLEGladiator
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30. One month after undergoing an uneventful renal transplant for chronic renal failure secondary to glomerulonephritis, a 38-year-old woman is hospitalized because of increased serum urea nitrogen (BUN) and creatinine levels. Prior to transplantation, she had been receiving hemodialysis for 3 years. Current medications include cyclosporine and prednisone. Examination shows no abnormalities. Over the past 48 hours, urine output has remained stable. Both renal biopsy and a radionuclide scan confirm the diagnosis of acute rejection. Which of the following is the most effective treatment?
A
) Immediate discontinuation of cyclosporine
B
) Increased dosage of corticosteroids
C
) Diuresis and alkalinization of the urine
D
) Renal dialysis for 1–2 weeks
E
) Transplant nephrectomy
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