clar697
Forum Guru
Topics: 190
Posts: 199
|
In a population, the frequency of the HLA-A locus allele (A*01) is 0.20 and the frequency of the HLA-B locus allele (B*08) is 0.20. In the same population, the frequency of the haplotype A*01, B*08 is 0.16. Which of the following terms best explains the population characteristics of the observed frequency of the A*01, B*08 haplotype?
A) Linkage disequilibrium
B) Random assortment
C) Somatic mutation
D) Variable expressivity
|
| seharmd
Forum Newbie
Topics: 7
Posts: 17
|
I think its A
linkage disequilibrium is the non-random association of alleles at two or more loci, not necessarily on the same chromosome. It is not the same as linkage, which describes the association of two or more loci on a chromosome with limited recombination between them. Linkage disequilibrium describes a situation in which some combinations of alleles or genetic markers occur more or less frequently in a population than would be expected from a random formation of haplotypes from alleles based on their frequencies. Non-random associations between polymorphisms at different loci are measured by the degree of linkage disequilibrium (LD).
|
|
| |
| | |
