clar697
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A 54-year-old man with alcoholism is brought to the emergency department because of a 10-day history of weakness, confusion, and shortness of breath. He drinks approximately three fourths of a liter of liquor daily. He appears wasted, and there is an odor of alcohol on his breath. His respirations are 32/min. Physical examination shows jaundice, abdominal distention, spider angiomata, and Tanner stage 2 gynecomastia. Laboratory studies show hypoalbuminemia and an increased serum estrogen-to-androgen ratio. The development of gynecomastia in this patient is mediated primarily by which of the following signal transduction pathways?
A) Activation of phospholipase A2 and generation of arachidonic acid
B) Activation of phospholipase C and generation of inositol 1,4,5-triphosphate
C) G protein-coupled activation of adenylyl cyclase
D) Receptor dimerization and autophosphorylation of tyrosine residues
E) Transmembrane diffusion and binding of signaling molecule to transcription factor
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| atulkalanuria
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E ?
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| Karime
Forum Guru
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E.....steroids (Estrogens) acts by direct DNA signals
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Eterea ……..“Hoc in loco mors succurrere vivis gaudet”…….
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| usmlekiller
Forum Guru
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E 
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FUTURE 99ER
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| maoudoody
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e
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| cooolguy
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that huge question stem just for that?
it seems to be E
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