clar697
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Tay-Sachs disease is an autosomal recessive disorder for which the carrier frequency in individual of Ashkenazi Jewish descent is about 1 in 30. On the basis of this carrier frequency, which of the following is the best estimate of the probability that a child born to two parents, both of whom are of Ashkenazi Jewish descent, will be affected by Tay-Sachs disease?
A) 1 in 15
B) 1 in 60
C) 1 in 450
D) 1 in 900
E) 1 in 1800
F) 1 in 3600
I chose D, 1 in 900 (30x30).
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| shaphat1
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I m not sure if you even need a calculation... im guessing A.. 1 in 15
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| gemma22
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F
30x30x4 = 1/3600 (don't forget it's autosomal recessive)
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| hitesh
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F) 1 in 3600
probability of either parent being a carrier = 1/30
Probability of both being carriers (necessary if the child has to get the disease) = 1/30 X 1/30
probability of a child getting a AR disease when both parents are carriers = 1/4
Overall probability of this child getting Tay Sachs = 1/30 X 1/30 X 1/4 = 1/3600
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| harrywfu
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D.
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| usmlekiller
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F no doubt
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| luckyme
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Good explaination Hithesh!I apreciate it.
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| hitesh
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Glad it helped 
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| aml
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F
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