clar697
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A 54-year-old woman has chronic symmetric swelling and tenderness in her proximal interphalangeal and metacarpophalangeal joints. She has muscle aches and stiffness, especially on awakening. Analysis of serum shoes antibodies able to bind human IgG. These antibodies are most likely to recognize which of the following pairs of labeled domains in the schematic diagram of an IgG molecule?
XX 1 5
XX 2 6
X---X
X 3
X 4
A) 1 and 2
B) 1 and 5
C) 2 and 3
D) 2 and 6
E) 3 and 4
F) 5 and 6
Edited by clar697 on 07/08/08 - 07:48 AM
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| jorgefhoyos
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I hope it's E.
I read somewhere that the fab fragments of Rheumatoid factor IgM bind to the FC portions of IgG.
Am I right?
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| ssrpk
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no its b....
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life is guud
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| jorgefhoyos
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^why's that?
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| clar697
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The confusion may be due to the poor illustration.
Rheumatoid factor (RF or RhF) is an autoantibody (antibody direct against an organism's own tissues) most relevant in rheumatoid arthritis. It is an antibody against the Fc portion of IgG. The Fc region is the tail region of the antibody. Answer is 3 and 4, choice E.
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| jorgefhoyos
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Dude, the illustration is fine. Thanks for posting all these q's Clar!
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