clar697
Forum Guru
Topics: 190
Posts: 199
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A 24-year-old man who is undergoing general anesthesia for an appendectomy develops a temperature of 40 degrees C (104 degrees F) and spasms of the masseter muscles. The adverse effect could be treated with a drug with which of the following actions?
A) Antagonism of acetylcholine receptors at the neuromuscular junction
B) Decrease of Na+-K+ ATPase in the skeletal muscle
C) Facilitation of Ca++ sequestration in sarcoplasmic reticulum of skeletal muscle
D) Increase of excitation-contraction coupling in skeletal muscle
E) Inhibition of acetylcholinesterase at the neuromuscular junction
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| DR_K
Forum Senior
Topics: 27
Posts: 123
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the correct answer is dantrlene use which occur thru dec calcium release from sarcoplamisc reti but as this is not given i wud chose B, is this the right ans???
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good luck(Y)
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| SpeaksSoftly
Forum Senior
Topics: 11
Posts: 148
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Yeha it's dantrolene, so does "Sequestering" Calcium mean decreasing it from being released? Because then my money would go on C.
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| microsporus
Forum Newbie
Topics: 0
Posts: 10
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C
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| Diego Casali
Forum Elite
Topics: 7
Posts: 234
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C for sure
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| supra
Forum Elite
Topics: 17
Posts: 342
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C
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| supra
Forum Elite
Topics: 17
Posts: 342
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http://www.jbc.org/cgi/content/abstract/272/43/26...
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| money45v
Forum Newbie
Topics: 0
Posts: 6
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The skeletal muscle relaxant dantrolene inhibits the release of Ca2+ from the sarcoplasmic reticulum during excitation-contraction coupling and suppresses the uncontrolled Ca2+ release that underlies the skeletal muscle pharmacogenetic disorder malignant hyperthermia; however, the molecular mechanism by which dantrolene selectively affects skeletal muscle Ca2+ regulation remains to be defined
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