clar697
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A 23-year-old man is brought to the emergency department by friends after he had a generalized tonic-clonic seizure at a party and became unconscious. His friends state that he had inhaled a large amount of cocaine 15 minutes ago. The patient is unresponsive and continues to convulse violently. Lorazepam is given. Administration of lorazepam is most likely to have which of the following electrophysiologic effects on the neuron?
A) Decreased influx of Ca++
B) Decreased influx of Na+
C) Increased influx of Cl-
D) Increased influx of K+
E) Increased influx of Mg++
I chose B, decreased influx of Na+.
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| atulkalanuria
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C ?
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| microsporus
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C
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| supra
Forum Elite
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C
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| SpeaksSoftly
Forum Senior
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C
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| Kikie
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C
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| sukkyman
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B
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| eddyheart
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Benzodiazapines and barbiturates act in the Cl channels.
Benzodiazapines (Lorazepan) increase the frequency(firing) of aperture of Cl channels.
Barbiturates increase the time (delay) of each aperture of the same channels.
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| chicago2008
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B. The anticonvulsant properties of lorazepam and other benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. Sustained repetitive firing seems to get limited, by the benzodiazepine effect of slowing recovery of sodium channels from inactivation in mouse spinal cord cell cultures.
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| maoudoody
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c
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| a3112
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C
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| brainstem
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C
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| ieltsforall
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c is the answer
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| adii
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I second eddyheart in that BZ potentiate GABA by increasing the frequency of Cl ion channel opening
therefore C.
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| vaibhavbora
Forum Elite
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benzo increaes frequency f cl ion channel .
brbs increse duration
i go with c
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