asmi
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A stressed myocardial cell that has no calcium gradient across its plasma membrane most likely has undergone which of the following processes?
A
) Abortive mitosis
B
) Adaptation
C
) Cell death
D
) Repolarization
E
) Reversible cell injury
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| mdwannabe
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E... with accumulation of Ca in mitochodria. :-)
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| mdwannabe
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Ca influx is hallmark of irreversible cell injury, as well as:
mitochondrial swelling and vacuolization
plasma membrane damage
lysosomal swelling
amorphous densities in the mitochondria
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| asmi
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So here it says no calcium at all ,so no influx..??so is it irreversible..then answer should be cell death .If its reversible than answer is E.
:roll: Q is confusing
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| mdwannabe
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Yes it is cell death.
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| sing
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hi, i am confused. is it C or E?
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| peekay
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AS EXPLAINED EARLIER I BELIEVE ANS=CELL DEATH
I THINK IT MAKES SENSE NO CALCIUM GRADIENT SO NO ACTIVITY IS GOING ( CELL DEATH) IF THERE IS AN ESTABLISHED GRADIENT IT MEANS CELL IS ALIVE AND WORKING AND IS ABLE TO ESTABLISH THAT GRADIENT.
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| Idiopathic
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An existing electrochemical gradient is a hallmark of a working cell, since it is always an active process. In this case, the cell has died, and is no longer establishing the gradient. Also remember that excessive Ca++ entry into the cell is often the earliest histological sign of cell death.
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| sing
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thanks.
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| asmi
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yes its cell death.
:idea: Its a very imp topic..plz read it in detail
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| mjl1717
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Addendum-Apoptosis is an active process regulated by genes and involves RNA and protein synthesis
"its a specialized form of programmed cell death"
there is dense eosinophilic cytoplasm and fragments and blebs.
there is no inflammatory response.
p53 stimulates apoptosis.
bcl2 inhibits apoptosis.
But to me this sounds close to coagulation necrosis
That is a thought provoking q asmi.
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| Cedrick
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Thanks for the addendum
C.Cell death
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