mash
Forum Fanatic
Topics: 147
Posts: 1,326
|
Which of the following causes a leukocytosis without an increase in the number of circulating polymorphonuclear neutrophil leukocytes?
A. Acute infection
B. Release of epinephrine
C. Tissue necrosis
D. Myelocytic leukemia
E. Collagen vascular disease
plz explain.
___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
epinephrine and corticosteroids both increase the circulating PMN numbers and decrease the marginating pool. they make it look like an infection with a leukocytosis, but there shouldnt be a left shift, I dont think.
|
| rida
Forum Guru
Topics: 109
Posts: 721
|
whats the answer?
___________________
"If He takes you to it, He'll take you through it."
|
| mash
Forum Fanatic
Topics: 147
Posts: 1,326
|
its B , release of epinephrine.
___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
Sorry, I should have said 'b'
|
| dr.shar
Forum Elite
Topics: 38
Posts: 236
|
requires explanation,,
|
| mash
Forum Fanatic
Topics: 147
Posts: 1,326
|
i dint get it so i asked someone to explain............
can someone do dat?
___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
The body's leukocytes exist in both the circulating pool (those that are in the bloodstream - actually measured in the differential) and the marginating pool (those that are attached to vessel walls even in the case of no inflammation - not measured in the differential). Epinephrine, cortisol, steroids all decrease the adhesive capabilities of the leukocytes and cause those that are stuck to the walls to become circulating. This will:
increase the circulating pool, and therefore increase the number of leukocytes measured with the differential (leukocytosis).
decrease the ability of the body to fight infection, since the leukocytes need to be able to adhere to the vessel walls to migrate through tissue in order to fight bugs.
note: this will be an absolute neutrophilic leukocytosis, because eosinophils and lymphocytes actully get decreased relatively, because they get sequestered in lymph nodes in this situation.
|
| rida
Forum Guru
Topics: 109
Posts: 721
|
Great explanation
___________________
"If He takes you to it, He'll take you through it."
|
| mash
Forum Fanatic
Topics: 147
Posts: 1,326
|
thanx a lot........i got it.
It is basically redistribution of PMNs dat leads to leucocytosis bcoz of release of epinephrine.
In all other conditions it is due to proliferative stimulus n there is increase in circulating neutrophils. right?
___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
Correct.
|
| rubensssss
Forum Guru
Topics: 95
Posts: 451
|
Idiopathic
Thanks a lot ,very, but very good explanation.
___________________
Ruben sssss
|
|
| |
| | | | | | | | | | | | |
