gingerbread
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Your patient is a 10 year old male who has had a history of muscle weakness, mild muscle wasting, and low tolerance to exercise since age 6. He has a normal fasting blood sugar and resting blood lactate is normal. However, the blood lactate increases dramatically upon exercise. Muscle creatine phosphate levels are much lower than normal. Which of the following is most likely defective?
A. Complex I of the ETC
B. pyruvate dehydrogenase
C. glycogen phosphorylase
D. malate-aspartate shuttle
E. carnitine acyltransferase
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| taipei817
Forum Junior
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A
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| gingerbread
Forum Newbie
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well, i thought about A, but we have to remember that the ETC is present in every aerobically glucose metabolizing tissue including the brain, heart, muscles, kidneys... so the symptoms are gonna be much more serious, relating to the '' indirect hypoxic'' injury to these tissues.. ( O2 is persent, but it's not utilized cuz the ETC is defective)....!!
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| littledoc
Forum Newbie
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C?
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