shazbaz wrote:
I'll give it a try
In alkalosis hydrogen leaves the cell and comes out where as potassium goes inside the cell to balance the charge. Therefore in alkalosis you will see hypokalemia meaning less potassium in the plasma. So in acute alkalosis intracellular potassium will be increased because of potassium going into the cell. Also in alkalosis there will be increased potassium in the distal tubular cell (intracellular concentration) so in alkalosis potassium excretion will be increased from normal. In acute condition this increased excretion wont have much effect on the intracellular concentration of potassium. therefore in acute alkalosis plasma potassium is decreased and intracellular potassium is increased. But in chronic alkalosis, the increased potassium excretion will have an effect of reducing the intracellular concentration of potasssium also. Therefore in chronic alkalosis intracellular and plasma potassium is decreased. Hope that made sense
yes it did !!! thanks a lot......can u explain the acidosis part as well?
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| Aashi
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In Chronic Acidosis--------------------->H+ from ECF moves into the cell to be buffered by Intracellular proteins , and to maintain the electrical neutrality K+ moves out of the cell into the ECF---------->So Hyperkalemia is seen in ACIDOSIS( coz hyper/hypokalmia is determined by the K+ Ion in the ECF not in the ICF)
In Alkalosis----------------->H+ is deficient in the ECF( hence the term" alkalosis"), so H+ moves from ICF-> ECF and to maintain the electrical neutrality K+ ions moves from ECF-->ICF-------------------->Hypokalemia, so hypokalemia is seen in Alkalosis
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| usmlekiller
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thanks aashi!!
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