arlete
Intern in 2009!!!!!
Topics: 36
Posts: 2,568
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It's a paradoxical effect. That's all I've read.
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When men make the rules, God decides the exceptions.
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| DR_K
Forum Senior
Topics: 21
Posts: 84
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coz acutely when diuretics r given given they worsen the situatuoin (that is the diabetes inspidus pt is already losing alot of water and u r giving them diuretics) so u give them weak diuretic like thiazides and thaizide saves water when given chronically bcoz when u force kidney 2 lose a Na+ chronically so dist convulated tubule and collecting duct try to absorb more Na+ even at the expense of K+ and H+ so all the watet which is made in diluting loop when comes distally gets absorbed by the DCT and CD and u dont need ADH to work on its recoptors(which as u know are resistant in the case of DI).
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| DR_K
Forum Senior
Topics: 21
Posts: 84
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guys i need feed back plz i searched alot on this ................ applause????
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| bioguy
Forum Guru
Topics: 59
Posts: 908
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Simply - Thiazides act on the DCT to lose Na and water thus forcing the PCT to absorb more Na and water. Why wouldn't that occur in the absence of NDI, I don't know.
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| bioguy
Forum Guru
Topics: 59
Posts: 908
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DR_K,
DCT and CD definitely needs ADH to absorb water. In the absence of ADH, or in resistance to ADH, DCT and CD are totally impermeable to water.
So the loss of Na and water due to Thiazides causes contraction of ECF volume thus increasing the Starling forces at the PCT to absorb more water.
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