hero
Forum Guru
Topics: 38
Posts: 517
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what is the difference btw varicella and zoster vaccines?
(i mean what - dose or mode of action - why can't use one for both?)
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| mukho
Forum Elite
Topics: 6
Posts: 534
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http://www.pbm.va.gov/monograph/Zoster%20Vaccine,...
there is a table describing the differences on page 3
19,400–207,000 PFU in zoster vs 1350–17,000 PFU in varicella
"In preliminary studies, higher potency vaccines were necessary to induce a significant cell mediated immune response to VZV in older adults. The minimum potency of the proposed Zoster vaccine is at least 14 times greater than the minimum potency of the vaccine approved to prevent varicella or chickenpox (Varivax). There is no evidence that the lower-potency vaccines would be efficacious in older adults in the prevention of herpes zoster or postherpetic neuralgia, and they are not recommended for this use."
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| hero
Forum Guru
Topics: 38
Posts: 517
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Thank you, mukho
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