sunny811
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76 year old patient with history of hypertension and diabetes has dry skin , cold intolerance, constipation . BMI is 27 . Treatment is started with Thyroxine . The patient is at increased risk of developing which of the following during 1st month of therapy ?
A. Angina pectoris
B. Asthma
C. Exopthalmus
D. Goiter
E. Jaundice
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| hottie99
Forum Guru
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a. angina pectoris; i remember being told in ck lectures that in elderly patients u always have to monitor their HR while taking thyroxine, bc they are sensitive to the changes and especially of the heart; the other choices dont make sense to be chosen... sorry it wasn't explianed better 
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| sunny811
Forum Newbie
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yea .. A seems to be the suitable one here ...
thx hottie
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| dkmj13
Forum Junior
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Good point hottie99
I agree, it is Angina pectoris. This I believe is because Thyroxine increases myocardial oxygen demand. DM would already have caused a vasculopathy.
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| GOGETA
Trying to get in PGY1
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A
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| maoudoody
Forum Guru
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history of hypertension and diabetes .....so she most probably astherosclerotic
thyroxine will increases sensitivity of receptors to catecholamines
increase heart rate ........> increases oxygen demand..........>astherosclerotic coronaries........> angina
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| supra
Forum Elite
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A
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