asmi
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37. A 2-year-old boy has a unilateral cleft lip and cleft palate. He has no other malformations and is otherwise healthy. He has no family history of birth defects. His parents are not related. Which of the following genetic mechanisms is most likely to have caused these congenital abnormalities?
A
) Autosomal dominant inheritance
B
) Autosomal recessive inheritance
C
) Chromosome aneuploidy
D
) Chromosome deletion
E
) Mitochondrial DNA mutation
F
) Multifactorial inheritance
G
) X-linked recessive inheritance
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| dr.shar
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F
) Multifactorial inheritance
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| rida
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C) chromosome aneuploidy
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| piter
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C) Chromosome aneuploidy
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| peekay
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I WILL SAY MUILTIFACATORIAL INHERITENCE
CHROMOSOAL ANEUPLOIDY WILL HAVE MORE THAN THAT( JUST ASSUMING)SINCE CHROMOSOME WILL BE INVOLVED IN MORE THAN ONE FUNCTIONS.
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| asmi
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cleft lip n plate has multifactorial inheritance but i am confused in this case with no family History :roll:
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| peekay
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I BELIEVE FOR MULTIFACTORIAL INHERITENCE FAMILY HX IS NOT IMP.( I AM NOT GOOD IN GENETICS ) PLEASE CORRECT ME IF U KNOW MORE ABOUT THIS TYPE OF INHERITENCE
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| rida
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According to my kaplan notes, Aneuploidy indicates deviation from euploid number of chromosomes, meaning a loss or gain of chromosomes. Two major types are trisomy (3 copies of a chromosome) and monosomy (one copy of a chromosome).
This example is trisomy 13, Patau syndrome, with oral facial clefts.
Monosomies and trisomes are usually caused by non disjunction.
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| peekay
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THERE ARE NO OTHER MALFORMATIONS.SO CAN'T BE TRISOMY 13
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| rida
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Actually Peekay i believe your rite, this site provides a good explanation of multifactorial inheritance:
http://med.usd.edu/som/genetics/curriculum/1GMULT...
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| piter
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thanx for info
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| asmi
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thanks rida..
so its multifactorial inheritence without any doubt 
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| rida
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no problem :o)
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