winnera
Forum Senior
Topics: 21
Posts: 86
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hi
after listening kaplan video and looking kaplan pharmacology i m confused that what should give first in organophoshprous poisoning , atropine or pam?according to video atropine first , according to lec notes pam APSP
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| doctor123
Forum Elite
Topics: 14
Posts: 370
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No No No
For symptoms like Mucle twitching, diarrhea, lacrimation, salivation appears, then give Paralidoxime
Atropine to keep HR above 60 ( to avoid bradycardia).
Its not that you should give which one first
Depending on Symptoms.
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| sahran
Forum Junior
Topics: 12
Posts: 44
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i think u must give pralidoxime assoon as possible because they compete with organophosphate for phosphorus receptor
so, if you don't give it asap , it will bind irreversibly with AChEIs
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| winnera
Forum Senior
Topics: 21
Posts: 86
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i see , thanks to doctor 123 and sahran.
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| hitesh
.
Topics: 61
Posts: 977
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Yes, there's a window where organophosphates bind reversibly to AChE and before an irreversible complex is formed. PAM needs to be given asap 'cos it helps only till this binding is reversible
Its true that atropine is for symptomatic management and support.
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