Genital lesion

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Genital lesion

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jean robert
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05/19/08 - 11:41 PM

A 37 yr old man presents to a physician because of a lesion on the shaft of his penis. On PE, a solitary , thickened, whitish plaque with slightly ulcerated, crusted surface is observed. Biopsy reveals markedly dysplastic epithelial cells, many mitoses (some of which are abnormal),disordered epithelial maturation, and an intact basement membrane with no evidence of stromal invasion.Which of the following is the most likely diagnosis?

a) Bowenoid papulosis

b) Bowen s disease

c) Condyloma acuminatum

d) Erythroplasia of Queyrat

e) Squamous cell carcinoma

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new_n_lost
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05/20/08 - 12:52 AM

b) Bowen s disease ??

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Tiff
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05/20/08 - 11:14 AM

B - Bowen's

jean robert
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05/21/08 - 07:41 AM

new_n_lost wrote:
b) Bowen s disease

EXPLANATION

This is Bowen s disease, which is one clinical form of Penile Carcinoma in situ (the other forms Bowenoid papulosis and Erythroplasia of Queyrat). Untreated Bowen s disease will, over a period of years, progress to frank invasive carcinoma in 10% to 20% of patients. Bowen s disease can affect the genital region of both men and women.

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jean robert
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05/21/08 - 07:45 AM

Bowenoid papulosis (choice A) is another form of penile carcinoma in situ, characterized by multiple reddish-brown papular lesions.

Erythroplasia of Queyrat (Choice D) is another form of penile carcinoma in situ, characterized by single or multiple shiny red papules

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