rida
Forum Guru
Topics: 109
Posts: 721
|
Can someone please explain the hardyweinberg concept to me, i can't see to understand it........ :cry:
___________________
"If He takes you to it, He'll take you through it."
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
Basically, it is this...assuming no mutation, genetic drift, etc:
Carrier rate corresponds to number of individuals who are heterozygotic for a specific allele (i.e. carriers). To figure out their risk of 'getting together' with another carrier, you multiply the two carrier rates (or frequencies) together. So, a carrier rate of 1/30 corresponds to a 'getting together' rate of 1/900. Now, if the condition is a somatic, autosomal dominant condition, you multiple the number 1/900 by the chance that the child will get the allele (1/2) and you get 1/1800. That is the chance that a random birth will be affected by an autosomal dominant condition where the carrier rate is 1/30. For autosomal recessive disorders, you multiply by 1/4 instead of 1/2.
If given the rate of phenotypic occurrence (i.e. how many births affected), you just work backward:
A rate of 1/10000 conceptions presenting with a certain autsomal recessive abnormality :arrow: 1/10000 divided by 1/4 for 'getting together' rate = 1/2500 :arrow: the square root of that is 1/50, which is the carrier rate/frequency in the population.
I hope this is what you wanted. This seems to be what the USMLE wants.
|
| rida
Forum Guru
Topics: 109
Posts: 721
|
THANK YOU SO MUCH I REALLY APPRECIATE IT, IT HELPS A LOT.....
___________________
"If He takes you to it, He'll take you through it."
|
|
| |
| | | |
