rubensssss
Forum Guru
Topics: 95
Posts: 451
|
what means costimulatory?
what is constimulatory signal?
___________________
Ruben sssss
|
| docshah
Forum Junior
Topics: 20
Posts: 56
|
In immune response, there are Antigen Presenting cells
(Eg. marcrophage,dendritic cells and B-cells), . They interact with the T-cells.
Now they Must ACTIVATE the T-cell! So they stimulate it when they interact with each otehr via the APC-and T-cell interaction. But along with the that, there is CO-Stimulation! Meaning ALong with the first stimulation to the t-cell, there is another stimulation. That is between the B7 on the APC cell and the CD28 on the T-cell.
Only with the APC and T-cell interaction and the costimulatory interaction, can the T-cell be activated!! :icon_thumb:
___________________
THINK POSITIVE, FEEL POSITIVE, BE POSITIVE!!!!
|
| docshah
Forum Junior
Topics: 20
Posts: 56
|
T cells require a TCR and a co-stimulatory signal like CD28 for activation
___________________
THINK POSITIVE, FEEL POSITIVE, BE POSITIVE!!!!
|
| StormBlade
Forum Newbie
Topics: 0
Posts: 27
|
costimulation increases il2 synthesis by 100 times and prevents clonal anergy
|
| jorgefhoyos
Forum Newbie
Topics: 1
Posts: 48
|
there's also the CD40 and CD40ligand co-stimulation
|
| StormBlade
Forum Newbie
Topics: 0
Posts: 27
|
it is for isotype switching .. CD40L is also called CD154.. Deficiency of it results with HyperIgM syndrome
|
| jorgefhoyos
Forum Newbie
Topics: 1
Posts: 48
|
I agree, but primarily it is costimulatory.
|
|
| |
| | | | | | | |
