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Author7 Posts
  #1

An obese man has been on a strict diet with very small amounts of CHO, yet serum chemistries show a low-normal level of glucose in his blood stream. Which of the following is the source of the majority of the newly synthesized glucose?

a.-Amino acids from protein degradation

b.-Ethanol synthesized by bacteria

c.-Fatty acids from fat breakdown

d.-Glycerol from fat breakdown

e.-Purine catabolism


___________________
Great works are performed not by strength, but by perseverance.

  #2

I go with choice D.

  #3

sigh wrote:
I go with choice D.


nodnod


___________________
Great works are performed not by strength, but by perseverance.

  #4

EXPLANATION

The amino acid degradation pathways that produce Oxaloacetate and Pyruvate can be used to synthesize glucose and are commonly stressed in biochemestry books. These pathways are important in TRUE STARVATION.

Also stressed in biochem books is that Acetyl-CoA cannot be used for gluconeogenesis, and thus FATTY ACIDS are not gluconeogenic. But this does not mean that "fat" cannot be used to make at least some glucose, since the stored fat is predominantly in the form of TG, and the glycerol backbone is glycogenic. Specifically , glycerol can be phosphated by glycerol kinase (which uses ATP) to form glycerol -3- phosphate, which can in turn enter the gluconeogenic pathway via oxidation to dihydroxyacetone phospahte.

This pathway contributes about 80% of the glucose in Dieting obese individuals, and about 20% of the glucose( behind the amino acid pathways) in truly starving individuals.


___________________
Great works are performed not by strength, but by perseverance.

  #5

Many amino acids (choice A) are gluconeogenic, but these pathways are most important in starvation than in dieting.


___________________
Great works are performed not by strength, but by perseverance.

  #6

nodnod Well done , sigh


___________________
Great works are performed not by strength, but by perseverance.

  #7

Thanks, now I feel so smart sticking out tongue







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