jean robert
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In the process of albumin synthesis, CHO chains that will be eventually transferred to the protein component of albumin are synthesized on which of the following substrate molecules?
a.- Arachidonic Acid
b.-Ceramide
c.-dermatan sulfate
d.-Dolichol
e.-hyaluronic acid
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| sigh
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I don't know the answer. Ceramide is lipid so it is out. Arachidonic acid is FA so it is not right. So, I pick up Dolichol
D.
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| jean robert
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wow !! U rock, buddy. 
Correct ans: D
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| jean robert
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EXPLANATION
In the synthesis of glycoproteins ( which are mostly with some attached sugars),the very long, phosphated lipid, Dolichol, serves as the substrate for forming the branched CHO "trees" that are then transferred to proteins.
This process occurs on the RER, and the resulting glycoproteins are then transferred to the Golgi complex for further progressing before incorporation into the plasma membrane, transfer to lysosomes, or release as secreted protein.
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| GoodGirl
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I thought that albumin is only one plasma protein which is not a glycoprotein. 
So when it is not a glycoprotein , why it would use the pathway of synthesis for glycoproteins ???
Edited by GoodGirl on 05/10/08 - 12:34 PM
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| GoodGirl
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Albumin does not contain a sugar residues and it was synthesized as prepro-albumin, it's signal peptide is removed as it passes through RER, and is further cleaved along the secretory pathway. Never heard about some CHO chain in case of albumin synthesis.
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| GoodGirl
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Anyone for discussion about that ?
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| GoodGirl
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Hallo..... just an echo.... 
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| new_n_lost
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Honestly i m still searching for that CHO connection that they have made.
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| GoodGirl
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I see, I'm kind a busy right now, although I tried to find something about it online, without any success.
But is that right , albumin is not a glycoprotein?
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| new_n_lost
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and the only thing i am coming up with is Diochol
"In addition, they play a role in protein N-glycosylation in the form of dolichol pyrophosphate by carrying the preassembled oligosaccharide Glc3-Man9-GlcNAc2 (where Glc is glucose, Man is mannose, and GlcNAc is N-acetylglucosamine) which is transferred to certain asparagine residues of nascent polypeptide chains."
This is from wiki. Now thats a stretch. I usually dont trust wiki so i will be looking for other sources.
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| new_n_lost
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It has been known for a long time that human blood proteins like hemoglobin [1] and serum albumin [2][3] may undergo a slow non-enzymatic glycation, mainly by formation of a Schiff base between ε-amino groups of lysine (and sometimes arginine) residues and glucose molecules in blood (Maillard reaction). This reaction can be inhibited in the presence of antioxidant agents [4]. Although this reaction may happen normally [5] , elevated glycoalbumin is observed in diabetes mellitus [6]. Wiki again
So not so sure about it.
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| GoodGirl
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Yes, but this is pathological , like in the case of DM, and not during synthesis of albumin.
( my son is in the bathtub  , running btw pc an him ) .
I opened Harper's biochemistry , seems like he talks about it more. Nothing in HY .
new_n_lost wrote:
It has been known for a long time that human blood proteins like hemoglobin [1] and serum albumin [2][3] may undergo a slow non-enzymatic glycation, mainly by formation of a Schiff base between ε-amino groups of lysine (and sometimes arginine) residues and glucose molecules in blood (Maillard reaction). This reaction can be inhibited in the presence of antioxidant agents [4]. Although this reaction may happen normally [5] , elevated glycoalbumin is observed in diabetes mellitus [6]. Wiki again
So not so sure about it.
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| new_n_lost
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Take your time with your son. I m still hunting for it.
GoodGirl wrote:Yes, but this is pathological , like in the case of DM, and not during synthesis of albumin. ( my son is in the bathtub , running btw pc an him ) . I opened Harper's biochemistry , seems like he talks about it more. Nothing in HY . new_n_lost wrote:
It has been known for a long time that human blood proteins like hemoglobin [1] and serum albumin [2][3] may undergo a slow non-enzymatic glycation, mainly by formation of a Schiff base between ε-amino groups of lysine (and sometimes arginine) residues and glucose molecules in blood (Maillard reaction). This reaction can be inhibited in the presence of antioxidant agents [4]. Although this reaction may happen normally [5] , elevated glycoalbumin is observed in diabetes mellitus [6]. Wiki again
So not so sure about it.
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| GoodGirl
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Harper's Biochem.
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| GoodGirl
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| GoodGirl
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What I understood from Harper's , that Dolichol is used only in synthesis of N-linked biosynthesis of glycoproteins, mainly of part of biologic membranes, what obviously albumin is not. There is a whole long chapter on it, who is in the mood to go trough it ?!
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| GoodGirl
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Jean Robert, if you don't mind, where is the Q from ? Send me a pm if you don't want here.
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| new_n_lost
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GG i m intersted in going thru that chapter.
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| jean robert
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GG, question is from Kaplan Qbank.
It seems that there s mistake in question stem. Or are we missing sthg?
Guys, i would like to get this point clear. Very soon I m gonna face the BEAST.
Plz help..
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| streakr
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Glycated albumin, also called fructosamine (old terminology) is normally found at low levels and when elevated, along with hemoglobin A1c, indicates hyperglycemia. Unlike A1c level, the 14 day half-life of albumin relegates glycated albumin to a two week retrospective view of hyperglycemia.
s
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