AngelT
Forum Senior
Topics: 27
Posts: 90
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Could someone help me to explain this question?
Thanks : )
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| hottie99
Forum Elite
Topics: 30
Posts: 427
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ok so this is essentially the concept behind nephrogenic DI rite? so what happens with diabedes insipidus is that ur serum osmolarity is increased and urine osmolarity is decreased b/c there is lack of ADH (in nephro DI, lack of renal response to ADH, or in central DI has no ADH in the brain from a pit tumor, trauma, etc..); so since ADH causes u to retain water, here it is opposite, u lose free water rite? so that's why their always peeing and thirsty...
so back to question.. now if we know serum osm is increased over the urine osm, which urine osm is decreased since u are just losing free water in ur urine.. now here is difference in nephorgenic versus central DI, nephrogenic HAS the ADH, it just doesnt work b/c the receptor is mutated and doesnt recognize it; but central does not have the ADH, which is why when u gve ADH injection after restricting water, u have an increase in ADH response in only central DI (bc essentially u are replacing the missing ADH that is absent in central DI).
so nephrogenic DI has the ADH floating around, it's just not working b/c the receptor doesnt work so u get no effct of ADH, but in central DI, have no ADH, so u need to supplement it, thus giving DDAVP to those patients. so i pick G, hope it helps! 
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