maojemes
Forum Newbie
Topics: 4
Posts: 5
|
6. Girl OD of paracetamol given N –acetylcyctine. Developed tachy, flushing, etc. Why ? igE hypersensitivity reaction/ disulfiram type reaction/
|
| acgz
Forum Newbie
Topics: 0
Posts: 1
|
Although both IV and oral acetylcysteine are equally effective for paracetamol overdose, oral administration is uncommon, as it is poorly tolerated, owing to the high doses required (due to low oral bioavailability), very unpleasant taste and odour, and adverse effects (particularly nausea and vomiting).
However, 3% to 6% of people given intravenous acetylcysteine show a severe, anaphylaxis-like allergic reaction (Hypersensitivity type I), which may include extreme breathing difficulty (due to bronchospasm), a decrease in blood pressure, rash, angioedema, and sometimes also nausea and vomiting (Kanter, 2006). Repeated overdoses will cause the allergic reaction to get worse and worse. Several studies have found this anaphylaxis-like reaction to occur more often in people given IV acetylcysteine despite serum levels of paracetamol not high enough to be considered toxic.
So, it is a tipic antigen cross-links IgE on presensitized mast cell and basophils.
|
|
| |
| | |
