boy w/ nosebleed and elevated PT, PTT

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boy w/ nosebleed and elevated PT, PTT

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6 Posts

step1000

Topics: 10
Posts: 29

05/02/08 - 01:17 PM

3 y.o boy w/ CF has uncontrollable nosebleed. no family history of bleeding dz. large bruises on legs. elevated PT and PTT. which treatment improve his cond.?
a. carboxylation of prothrombin
b. conversion of homocysterine to methionine
c. farnesylation of ras
d. hydroxylation of procollagen
e. phosphorylation of pyruvate DH

what 's the Dx?

thanks.

doc499
Forum Senior
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Topics: 2
Posts: 158

05/02/08 - 01:58 PM

where did u find this ques?i wud go for b or d.

basophilia
Forum Junior
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Topics: 6
Posts: 126

05/02/08 - 02:02 PM

rpta . A. pac with cf def of vit ADEK , so def vit k .

step1000

Topics: 10
Posts: 29

05/02/08 - 02:24 PM

the answ is a.

i was confused for a while. somehow it clicked now.

prothrombin is clotting factor II which is a common factor in both extrinsic and intrinsic pathways. therefore both PT and PTT is elevated. since there is decrease in thrombin, bleeding time would prolong.

the above is just my thinking. please let me know if i m wrong. thanks guys.

kamran865
Forum Newbie

Topics: 0
Posts: 4

05/03/08 - 10:42 AM

ur options are ridiculous, simple elevated PT, APTT,normal correction test means, def of any common pathway factor, 2, 5, 10

jean robert
Forum Guru
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Topics: 145
Posts: 598

05/05/08 - 12:51 AM

step1000, increase bleeding time (BT) is ONLY related to PLATELETS abnormalities.

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