cheech
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Boy_Wonder,
its not that I don't enjoy the material, just that some days ( espcially last week) I just get tired of being in da library and studying. I admire u determination. Keep up the good work. Ur journal is definately motivating!!
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| dowjunk
Forum Elite
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Cool post!!! i love the way u post important points.........hope to see it coming....its pretty informative for us!
Well!!!!!!! keep it going!
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Grad of 2007. Work in progress.......
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| Boy_wonder
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I'm back and ready to go. Exams finished. 
So achievements today so far include:
1) started Kaplan Internal Medicine
2) finished amino acid part of biochemistry
3) just review a part of histology so I will see here if I can recall what I learned with you:
Disease: Deficiency
Gaucher's: glucocerebrosidase
Nieman Pick's: sphinogmyelinase or NCP 1/2
Tay Sachs: hexosaminidase A
Hurlers: alpha L iduronate
Hunters (X-linked recessive): iduronate sulfatase
Fabrys: alpha galactosidase A
Farbers: ceramidase
Metachromatic leukodystrophy: arylsulfatase A
Krabbe: galactosylceramidase
Refsums: faulty alpha oxidation of phytanic acid
Zellweggers: PEX 2 deficiency
Acatalasia: absence of catalase
Infantile adrenoleukodystrophy: PEX proteins
Peroxisomes:
* beta oxidation of fatty acids
* bile acid synthesis
* contain catalase
Hope everyone is going well
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| ocano
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Hi man !!
I am international stud and starting also... have very few time but trying to do my best.
those notes about ur reviewed things will be very helpful.
Thanks a lot
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| Boy_wonder
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No problem ocano, can't say I will be putting up everything I read, but If I come across things that are interesting to me or often not studied by other students then I will write them up. Just call in for a look.
Have been working consistently over the last few days and am working my my way through both biochemistry and genetics. I think another week and a bit should have these.
Might write up some more histology after I review it tonight. Hope study is going good for all of ye out there. Keep it up. It's very doable just keep going.
All the best, Boywonder.
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| dowjunk
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Can you remember these horrendous disease deficiency links! it just flows out of ma head like vapors! Keep it going, u r impressing us all!
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| Boy_wonder
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Ya I know what your saying dowjunk. It's hard to remember them all, I'm even forgettin histology I did a month ago.
But it's all part of the process.
When I review them again they will come back qucker than the first time, and as Goljan says, it shouldn't all be about memorisation either.
Hopefully it will become instinctive.
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| Boy_wonder
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So what have I been up to recently:
Well I've continued to study Biochemistry and hope to finish in 2 weeks time.
I'm also studying Genetics right now from a great book Genetics in Medicine: Thompson and Thompson.
Furthermore, I've listened to 7 audio of Goljan and I've read GI of Kaplan Internal Medicine.
I'm also reading Churchill's Pocketbook of Surgery 10 pages a day.
Things going good.
Today's little note: LOD score > 3 is a definitive evidence of linkage of two alleles.
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| Boy_wonder
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Dowjunk raised a valid point: how are we going to remember this stuff: So I'm going to share my memorisation techniques with you from today on, starting with biochemistry.
Let's start with nonpolar amino acids:
Nonpolar or to put it another way, not polar. When you see nonpolar I want you to think of a place like the north pole, all snowy and wintery but not quite the north pole, kind of like that Sylvester Stallone movie, Cliffhanger.
Sylvester's nickname is sly which kind of sounds like gly....or glycine which gives us our first nonpolar amino acid.
To continue, sly decides to go alan from the show two and a half men somewhere. Alan is short for alanine which gives us our second nonpolar amino acid.
Their destination is vermont, because as alan puts it "I love vermont": giving us isoleucine, leucine and valine.
In reality this vermont escapade was a ruse to the general public, because they were going to get married and meet people.
Married for methionine and people for proline and phenylalanine.
There is my technique, the more absurd you make the imagery, the more it will stick in your mind. Let me know what ye think and if ye want me to continue.
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| Boy_wonder
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To remember the polar amino acids requires a roundabout route e.g. if you know the nonpolar, acidic and basic amino acids then you can derive which are the polar ones.
Acidic amino acids are pretty easy as its all in the name: glutamic acid and aspartic acid.
Basic amino acids require some imagery. Basically Hal likes to argue a lot:
HAL:
Histidine, Arginine and Lysine with argue giving you argggginine and liiike giving you lyyyyysine!
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| study499
Forum Guru
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no wonder why yr name wonders
of course continueeeee & thankssss
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| Boy_wonder
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A challenge: Without reviewing your notes, can you explain the exact reason why HbS does not migrate downwards in gel electrophoresis as quickly as HbA in Sickle Cell Disease.
Will answer this later on.
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| Boy_wonder
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HbS occurs due to the substituion of valine for glutamic acid. In essence this is the substitution of a nonpolar amino acid for a polar amino acid.
Hb migrates towards the anode (+) end during gel electrophoresis. A nonpolar amino acid would therefore migrate less quickly then HbA.
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| dowjunk
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Bingo! you are the new 'cool' kid in town! Cheerz pal!
all ates and tates are neg charged (glutam, aspart)..........neg charges move towards the +ve poles faster. Valine is non polar (vermont the destination of the non polar imagery)
thx, helps me for sure!
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| dowjunk
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I am sorry to say this, but I love it when i peek in ur journal! Just keep the flow.
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| Boy_wonder
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Thanks dowjunk. Hope you and others call in more often!
A few weeks ago I touched on lysosomal storage diseases so tonight I thought I would talk about Tay Sachs and Sandhoffs disease for a moment as both are closely related.
These GM2 gangliosidoses result from the inability to degrade a sphingolipid, namely GM2 ganglioside. They primarily affect the brain.
Catalytically active hexosaminidase A is the product of a 3-gene system. These genes encode the alpha and beta subunits of the enzyme. Tay Sachs is associated with deficiency of the alpha subunit and Sandhoff disease is associated with the beta subunit.
The end result is the enzyme cannot cleave between N-acetylgalactosamine and galactose.
Clinically, one finds a cherry red spot on the retina and progressive neurological dysfunction.
To remember this: think about eating cherrys from a sack on a sandy beach with david hasselhoff.
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| Boy_wonder
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A 35 year old non-smoker with emphysema is admitted to A and E with shortness of breath and hepatomegaly. Examination of his hepatocytes would reveal which of the following:
a) enlarged lysosomes
b) accumulation of protein in rough endoplasmic reticulum
c) accumulation of glycogen
d) increased intracellular haemosiderin
e) zone 2 necrosis
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| supra
Forum Elite
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hi boywonder,nice 2 read ur journal,GL with ur studies.
by the way,i vote for option 2-alpha¹ anti -trypsin deficiency
?
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| Boy_wonder
Forum Newbie
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Ya option b is the correct one, made up the question myself, but just highlights how they could question your histology given what you already know.
Alpha 1 anti-trypsin deficiency is associated with accumulation of Z protein in RER. Remember Z allele?
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| dowjunk
Forum Elite
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alpha1antitrypsin right....but never new this histoconcept of Zprotein in RER!!!
I have been doin histo from BRS....and i know taysachs but never went this deep !
BOYWONDER, thanks for showing me my weakness! luvya buddy!
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