Prep4USMLE Forum » USMLE Step 1 Forum » Immunology Forum |   NBME 2: LPS mediated activ. of transcrip

Author	10 Posts
step1000 Forum Junior Topics: 12 Posts: 33	05/01/08 - 04:52 PM             #1 TNF is the primary mediator of hose responses initiated by LPS and leading to septic shock. LPS-mediated activation of transcription most likely depends on which o of TF? A. c-ras B. nuclear factor -kappa B C. p53 D. Rb ptn E. VP-16 (etoposide) the answ. someone gave was B. i don't know why. plz help
lakshya_0_7 Forum Elite Topics: 24 Posts: 314	05/02/08 - 04:29 AM             #2 yah it should be B............ the LPS actually binds to what are called "toll like receptors " - CD-14...on the
lakshya_0_7 Forum Elite Topics: 24 Posts: 314	05/02/08 - 04:30 AM             #3 yah it should be B............ the LPS actually binds to what are called "toll like receptors " - CD-14...on the macrophages.........an
lakshya_0_7 Forum Elite Topics: 24 Posts: 314	05/02/08 - 04:35 AM             #4 and activates the cascades in the cytoplasm and then the nucleus that causes release of cytokines like IL-2 etc etc.......and the pathway for IL-2 involves NFkB and someother proteins like "calcineurin" etc etc (most immunosupressive drugs also act to inhibit this pathway ) ... rest all options are related to oncogenesis and stuff........
step1000 Forum Junior Topics: 12 Posts: 33	05/02/08 - 10:46 AM             #5 lakshya, is CD14 the TLR? the answ is b.
lakshya_0_7 Forum Elite Topics: 24 Posts: 314	05/02/08 - 12:02 PM             #6 well i duuno exactly...but yah...in the cascade of events...CD-14 is activated and the TLR are activated.....*both on the macrophages*...need to check the book!
jean robert Forum Guru Topics: 162 Posts: 669	05/02/08 - 01:32 PM             #7 NF-κB plays a key role in regulating the immune response to infection. Consistent with this role, incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory. " wikipedia" ___________________ Great works are performed not by strength, but by perseverance.
jean robert Forum Guru Topics: 162 Posts: 669	05/02/08 - 01:35 PM             #8 Many bacterial products can activate NF-κB. The identification of Toll-like receptors (TLRs) as specific pattern recognition molecules and the finding that stimulation of TLRs leads to activation of NF-κB improved our understanding of how different pathogens activate NF-κB. For example, studies have identified TLR4 as the receptor for the LPS component of Gram-Negative bacteria. TLRs are key regulators of both innate and adaptive immune responses. "wikipedia" ___________________ Great works are performed not by strength, but by perseverance.
step1000 Forum Junior Topics: 12 Posts: 33	05/02/08 - 03:45 PM             #9 CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide
step1000 Forum Junior Topics: 12 Posts: 33	05/02/08 - 03:47 PM             #10 macrophages then present Ag particles to Th1 cell which then produce IL 2 thanks Lakshya and Jean

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