crista
Forum Guru
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A 70-year-old Caucasian woman, previously healthy,
develops fatigue, weakness, and exertional dyspnea. The physical examination reveals only pallor. An anemia is detected
with a hemoglobin concentration of 7.0 g/dL and an hematocrit of 21% with an MCV of 105 fL. The white blood cell count is
8,000/µL and the platelet count is 510,000/µL. The bone marrow is hypercellular. Red cell precursors are reduced in number.
Megakaryocytes are smaller than normal and most have a single, round nucleus. Which of the following is most likely to be
found?
A. Mitochondrial iron deposits in erythroid precursors.
B. Translocation of DNA from chromosome 9q to chromosome 22.
C. An abnormal first stage Schilling test, but a normal second stage.
D. Deletion of the long arm (q) of chromosome 5.
E. Blasts containing Auer rods in the blood and marrow
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| mistral92
Forum Senior
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C. abnormal schilling test???
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| mdwannabe
Forum Guru
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A I think. Looks like Chronic myelofibrosis.
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| peekay
Forum Guru
Topics: 102
Posts: 588
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reduced number of megakaryocytes and increased platelet count, this is probably not true for myelofibrosis.on the other side no other physical findings and hard to decide if it really is megaloblastic anemia.
any way based on lab findings i will pick
ANS=C
what is the answer or is this one of those qs with no answer.
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| crista
Forum Guru
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yes,it is one of those qs with no answer.
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| mdwannabe
Forum Guru
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Posts: 1,133
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in myelo ffibrosis.. Megakarys are increased, but smaller. If it is C... how would u explain BM findings?
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"Life not lived for others, is not worth living" Uncle Einstein
"A life is not important, except in the impact it has on other lives" -Jackie Robinson
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| peekay
Forum Guru
Topics: 102
Posts: 588
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IN THIS PT THERE IS DECREASED NUMBER OF RBC PRECURSORS.AND PLT COUNT IS INCREASED.IF THIS IS MYELOFIBROSIS THAN THERE SHOULD BE REPLACEMENT OF CELLULAR COMPONENTS WITH FIBROSIS ON B.M BIOSY FINDINGS AND ESSENTIALLY REDUCED CELL COUNT.I AM STILL WORKING ON THIS.
PLEASE ADD MORE EXPLANATION IF YOU CAN.
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