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Proliferative activity
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Author7 Posts
  #1

A biopsy of a brain tumor from a 42 year old man reveals a glial neoplasm consisting of atypical astrocytes with scattered mitoses. Besides mitotic activity, which of the following markers can provide information about the neoplasm s proliferative activity?

a) bcl-2

b) Glial fibrillary acidic protein (GFAP)

c) Ki-67

d) p53

e) Ubiquitin


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  #2

Wow! This is hard one. Not D, not A for sure... Will go with C...just intuition...have no idea what is Ki-67...

  #3

Ki67. Nuclear marker for cell proliferation.


  #4

Till i think so , Ki-67 is answer for it

i have got some information on Ki-67, this can be helpful.

The expression of the human Ki-67 protein is strictly associated with cell proliferation. During interphase, the antigen can be exclusively detected within the nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. The fact that the Ki-67 protein is present during all active phases of the cell cycle (G(1), S, G(2), and mitosis), but is absent from resting cells (G(0)), makes it an excellent marker for determining the so-called growth fraction of a given cell population.

  #5

Thanks Drshreyas!

  #6

sigh wrote:
Wow! This is hard one. Not D, not A for sure... Will go with C...just intuition...have no idea what is Ki-67...

nod


___________________
Great works are performed not by strength, but by perseverance.

  #7

Drshreyas wrote:
Till i think so , Ki-67 is answer for it

i have got some information on Ki-67, this can be helpful.

The expression of the human Ki-67 protein is strictly associated with cell proliferation. During interphase, the antigen can be exclusively detected within the nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. The fact that the Ki-67 protein is present during all active phases of the cell cycle (G(1), S, G(2), and mitosis), but is absent from resting cells (G(0)), makes it an excellent marker for determining the so-called growth fraction of a given cell population.


Good explanation nod


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