krsma
Forum Elite
Topics: 40
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Why can't you treat it by giving immunoglobulins?
** kaplan notes states that you treat it with antibiotics, not Igs.
can anyone explain!! thanks
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| mistral92
Forum Senior
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hi i'm not sure about the answer but i think that we can't give to this patients IgA or transfuse them because of the risk of the anaphylaxis ( increase autoimmunity) may be that they act as a foreign body....????)
what about live vaccine in that case...???
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| Gul
Forum Elite
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Yes, the only exception that i have read is IgA deficiency
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| mdwannabe
Forum Guru
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I think Ig are used, only they are expensive, especialy used in transient hypogamma.
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| mistral92
Forum Senior
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hi mdwanabbe i'm quite sure that in case of IgA deficiency we can not give IgA ...for transfusion i have a doubt ( but i think that the contra indication is due probably to the presence of foreign IgA
treatment antibiotics.
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| mdwannabe
Forum Guru
Topics: 37
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I agree, I guess I misunderstood the q :-) sorry, I thought we were talking about general treatment principle. In IgA def, there are possibly anti-IgA AB, hence, the possibility of transfusion rx, du to same AB, and those AB would prevent infused IgA from working and create serum sickess type synd. Also, how would it get to its primary site of action? It should be on epith surface to be usefull, not in plasma, and it has a 1 wk T1/2 , makes it for many injections to keep concentration high enough.
Thats my line of reasoning.
___________________
"Life not lived for others, is not worth living" Uncle Einstein
"A life is not important, except in the impact it has on other lives" -Jackie Robinson
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