Class II antigens

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Class II antigens

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jean robert
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04/28/08 - 07:11 PM

A 54 year old man presents with complaints of shortness of breath, a sore tongue, and "pins and needles" sensation in his feet. Lab examination reveals macrocytosis, anemia and hypersegmented neutrophils. Antibodies to Intrinsic factor are detected in the patient s serum. Which of the following class II antigens would be most likely to play a contributing role in the etiology of this patient s disease?

a) DR2

b) DR3

c) DR4

d) DR5

e) DR7

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taipei817
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04/28/08 - 07:30 PM

Black_curtain
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04/28/08 - 07:42 PM

ok cant remember where but i have read about this somewhere but not sure between DR 2 or DR 3.

sigh
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04/29/08 - 11:29 AM

D. DR5
Mnemotic: "Now, I'm five, I've traded my juvenille DM (DR4) for Juvenille RA...I hope it will go away before I "B 12" (pernicious anemia)

taipei817
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04/29/08 - 03:22 PM

cool sigh. many thx nod

jean robert
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04/29/08 - 05:01 PM

sigh wrote:
D. DR5
Mnemotic: "Now, I'm five, I've traded my juvenille DM (DR4) for Juvenille RA...I hope it will go away before I "B 12" (pernicious anemia)

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jean robert
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04/29/08 - 05:06 PM

EXPLANATION

Pernicious anemia is associated with the DR5 class II antigen; DR5 is also associated with Juvenile Rheumatoid Arthritis

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jean robert
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04/29/08 - 05:16 PM

Diseases associated with DR2:

1.-Goodpasture syndrome

2.-Allergy

3.-Multiple sclerosis

4.- Narcolepsy

Diseases associated with DR7:

1.-Steroid-responsive Nephrotic Syndrome

Edited by jean robert on 04/29/08 - 05:23 PM

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jean robert
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04/29/08 - 05:20 PM

Diseases associated with DR3:

1.-Celiac sprue

2.-SLE

3.- Type 1 DM

Diseases associated with DR4:

1.-Type 1 DM

2.-Rheumatoid Arhritis

3.- Pemphigus Vulgaris

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sigh
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04/29/08 - 05:23 PM

#10

MNEM for HLA-DR2...each has "two": Goodpasture- 2 systems (lungs and kidney), MS- 2 letters (M and S), narcolepsy: two sleepy...Maybe, someone can add something for allergy?

GOGETA
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04/29/08 - 05:36 PM

#11

You need to know those things very well they ask about that frecuentl on the exam
will be some easy points if you know everyhting about that

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