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UW: Schizophrenia Treatment Question
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Author3 Posts
  #1

A 38 year old man with chronic Hx. of Schizophrenia... Admitted for deterioration of his condition. He is known to you and was stable on his resperdone for the past few years. Today the patient does not respond to you and sits motionlessly. He makes no eye contact. His face is expressionless. Vitals are normal and exam shows diffuse muscle rigidity, but is otherwise unremarkable. What is the next best step?
A. Increase Risperdone
B. Initiate Dantrolent Sodium
C. Replace Risperdone with Quetiapine
D. Continue same dose of Risperdone and add Clozapine
E. Administer Lorazapam

-Also: WHAT IS THE DIAGNOSIS in this case (his presentation is due to ______?)
AND:
-How can you tell the difference between the rigidity due to catotonic schizphrenia vs. the rigidity due to EPS from antipsychotics?


___________________
Our greatest glory is not in never falling, but in rising every time we fall.

  #2

i m working in psy dept as a res.n i hav come accross a pt with this pic
i would add clozapine 2 his resp-d'
eps are usually seen in the initial phase of anti dopamine antipsy
this gentle most probably has a relapse/so i would like 2 addd cloz which acts diff
add a note 2 check his CBC


  #3

drcrish wrote:
i m working in psy dept as a res.n i hav come accross a pt with this pic
i would add clozapine 2 his resp-d'
eps are usually seen in the initial phase of anti dopamine antipsy
this gentle most probably has a relapse/so i would like 2 addd cloz which acts diff
add a note 2 check his CBC


Hi drcrish.
Thanks for your reply. Actually the right answer is
E. Administer Lorazapam
The explanation says this is:
Catatonic Schizophrenia which is best treated with a Benzo or ECT!

The question at first could seem like Rigidity as a side effect (typical antipsychotics cause EPS), however this patient is on Risperdone, an atypical antipsychotic which is less likely to cause EPS, and furthermore he has been stable on his risperdone for the past few years. If EPS were to show up, Rigidity would occur in the "initial phase" of treatment as you mentioned, so this is not a side effect of medication, rather its the Schizophrenia itself...
I was just interested that Catotonic Schizophrenia is best treated with Benzos and ECT, instead of the antipsychotic meds.
Anything else to add?


___________________
Our greatest glory is not in never falling, but in rising every time we fall.







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