hottie99
Forum Elite
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can anyone explain why it is C?? thx!! i would have thought atp depletion would be the cause from the hypoxia, no??
Edited by hottie99 on 04/22/08 - 02:43 PM
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| taipei817
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hi, anyway u could post it in a picture format? thanks.
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| hottie99
Forum Elite
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wat do u mean? i dont know how to do that 
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| basophilia
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E influx of NA , because they said mitocondrial swelling and is in seconds that is reversible yet
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| hottie99
Forum Elite
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yes but for influx of sodium, doesnt the membrane have to degrade?? the ans that came with nbme said C, so i dont know if it's wrong or what, i figured most of those answers were rite! 
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| taipei817
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(i got the question) the mitochondrial findings indicate irreversible cell injuries. it will lead to cell death. thus the choice C, which is the only association to irreversible injury to a cell among the other choices.
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| hottie99
Forum Elite
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ok but wouldnt the initial cause be hypoxia then, so atp depletion isn't rite??
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| taipei817
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it would occur but considered reversible. the mitochondria finding indicates it is irreversible. so atp depletion is not enough, we need a finding that indicates irreversible injury,which would be membrane destruction
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| hottie99
Forum Elite
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aaah thx so much taipei!! i relaly appreciate it, so like the other irreversible findings like the lysosomal damage and the nuclear pyknosis nd suh, wat causes those things, same thing as membrane degradation?? and how is the membrane being degrade? due to lack of o2 or how so?? appreciate u help!!
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| taipei817
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membrane is one the last defense a cell has, if it loses it, calcium will flow in, ph will change, protein will misfold etc. pyknosis of the necleus is seen in apoptosis, which could be secondary to mitochondria damages (via release of cytochrome c?). lysosomal damages are also irresversible and may also be 2nd to memrane damage but maybe there are other causes of direct lysosomal damages, i cant think of one at this moment.
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| taipei817
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just checked robbins, pyknosis-->karyorrhexis-->karyolysis is seen in necrosis, meaning there were a irreversible cell injury.
also, robbins (PBD 7th) pp19 says "two phenomena consistenently characterize irreversibility: the first is the inability to reverse mitochondrial dysfunction ... ... the second is the develioment of profound disturbances in memrance function....
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| Tiff
Forum Guru
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I must be the only one who can't see these questions.
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| Tiff
Forum Guru
Topics: 50
Posts: 505
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I must be the only one who can't see these questions.
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