Vitamin E deficiency

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Vitamin E deficiency - help

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Tiff
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04/20/08 - 05:42 PM

How does Vitamin E deficiency cause apolipoproteinemia? I understand that vit. E prevents LDL oxidation, but how does it cause this. Apolipoproteinemia happens becuase of a lack of apoB lipoproteins. I'm just not seeing the connection. raised eyebrow

hottie99
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04/20/08 - 06:19 PM

yah i just did that today in HY goljan stuff, and even in treatment he posted as vit e, when apolipoproteinemia has deficient in all fat soluble vitamins, so i was confused about that too... i'll brb to look up some stuff perhps..

hottie99
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04/20/08 - 06:50 PM

ok think i found something.. something to do with mttp mutations that lead to abetalipoprotienemia.. and fat soluble vitamins are necessary for mttp, check out this site:

http://ghr.nlm.nih.gov/gene=mttp

then read on this about abetalipoprotienemia and how mttp is in that:

http://ghr.nlm.nih.gov/condition=abetalipoprotein...

hope that helps! cool

Tiff
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04/20/08 - 07:33 PM

Thanks for the links. Really helps. I guess it's not as complex as I thought. Just really has to do with absorption of vitamins. Here is something I found.

"Most of the clinical symptoms of ABL are the result of defects in the absorption and transport of vitamin E. Normally, vitamin E is transported from the intestine to the liver and is then repackaged in the liver and incorporated into the assembling VLDL particle by a specific protein termed the tocopherol-binding protein. In the circulation, VLDL is converted to LDL and vitamin E is transported by LDL to peripheral tissues and delivered to cells via the LDL receptor. Patients with ABL are markedly deficient in vitamin E because of the deficient plasma transport of vitamin E, which requires hepatic secretion of apoB-containing lipoproteins. Most of the major clinical symptoms, especially those of the nervous system and retina, are primarily due to vitamin E deficiency. This hypothesis is supported by the fact that other disorders involving vitamin E deficiency are characterized by similar symptoms and pathologic changes." http://www.emedicine.com/med/byname/Low-LDL-Chole...(Hypobetalipoproteinemia).htm

hottie99
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04/20/08 - 08:22 PM

well i mean it makes sense that vit e deficiency is because of the ABL rite?? but i thought u were asking if vit e deficiency CAUSES ABL?? b/c does it?? i didn't think so, unless this tocopherol is being said in lieu of vit e (isn't alpha-tocopherol = vit e)?? uugghh!!

Tiff
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04/20/08 - 08:33 PM

Well actually, it could be a matter of how I'm understanding Goljan. I haven't read anything else that suggests the Vitamin E deficiency causes apolipoproteinemia. What I've read everywhere is that apolipoprotenia causes Vitamin E deficiency. And we can see why? It only makes sense this way. I think you'd agree. smiling face

hottie99
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04/20/08 - 09:10 PM

yes ma'am! the malabsorption, where in goljan notes is it, i too thought it was in thre, but couldnt find it, drove me nuts!! they need indexes!! raised eyebrow

Tiff
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04/21/08 - 09:05 AM

hottie99 wrote:
yes ma'am! the malabsorption, where in goljan notes is it, i too thought it was in thre, but couldnt find it, drove me nuts!! they need indexes!! raised eyebrow

Don't even know anymore. Have to look.

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