come on 99ers, please help me!!!

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come on 99ers, please help me!!!

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hottie99
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04/20/08 - 02:31 PM

what is ssecond messenger for retinoic acid receptor?? any thoughts! raised eyebrow

Tiff
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04/20/08 - 02:57 PM

I think IP3/DAG. I'll have to look it up to confirm.

hottie99
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04/20/08 - 03:13 PM

hey thx, i just droped a note in the FA post, my bads! yah my friend she was saying perhaps cGMP b/c it's association with vit A, and vit A uses the cGMP Na+ channels.. dont know.. i thought maybe like kinase something.. or figured it's like steriod hormones b/c it's fat soluble.. god knows..

Tiff
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04/20/08 - 03:23 PM

After trying to look this up, I haven't found any evidence that it uses a G protein. It's considered a steroid hormone which is lipophilic and uses a steroid receptor. Retionoic acid specifically along with thyroxine has their receptor on the nucleus and not the cytosol (like other steroid hormones). Hope I've helped. Maybe someone else can weigh in.

hottie99
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04/21/08 - 06:50 AM

HELP PLEASE!!!! thanks nod

mukho
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04/21/08 - 07:29 AM

Retinoic Acid receptors (RARs) are nuclear receptors related to the steroid and thyroid hormone Receptors, a family of proteins that function as ligand-dependent transcription factors. As with other enhancer-binding proteins, nuclear receptors act as transcription factors by binding to specific DNA recognition sequences generally located upstream of responsive genes.

i dont remember much of biochemistry but the above suggests maybe they dont have second messengers

drshvetasm
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04/21/08 - 07:41 AM

i think its calcium...but not too sure...please confirm this..

mukho
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04/21/08 - 07:50 AM

http://pre-pg.blogspot.com/2006/07/second-messeng...

try this link....at the end of the page, they say its nuclear receptors

drshvetasm
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04/21/08 - 08:24 AM

i think its calcium...but not too sure...please confirm this..

drshvetasm
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04/21/08 - 08:25 AM

#10

http://www.jbc.org/cgi/content/abstract/271/25/15...

hottie99
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04/22/08 - 04:34 PM

#11

ok but wat if nuclear receptors wasn't a choice, it was like cGMP, cAMP, calcium.. the usual choices.. i too thought it was nuclear recpetors, but i dont know.. so hard! shocked

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