sport29883
Forum Newbie
Topics: 2
Posts: 3
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Hey all,
I would like to start a post for any doubts/questions you come across when reading Kaplan notes. For all to understand, I think we could write the page number followed by the statement and question. Heres my first one-
pg 8- It says the concentration of albumin is usually much higher than the concentration of the drug bound to it. A definite percentage for each drug binds, and remainder is the free fraction.
My question is-what are the factors which decide how much of a drug binds to the albumin, and how much is the free fraction?
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| icarus
Forum Senior
Topics: 27
Posts: 149
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I dont have an answer for this particular question, but i think that it has something to do with each drugs conformational chemistry, for example Warfarin is 98% bound, but no one ever mentioned the reason for such great affinity to albumin ...
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| sport29883
Forum Newbie
Topics: 2
Posts: 3
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yes..that is what I think so too. If you ever come across some reference, do put it up. Will do the same. Thanks
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| DR_K
Forum Junior
Topics: 17
Posts: 46
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i think the bound/unbound form is determined by over all everything and competetion of things to get attached to albumin, think that if for instance drug "X" is 30%in bound form so remainder of the drug is free but not albumin, ie remainder albumin is is bound to other important things like hormones other drugs etc so it the overall competetion among drug "X",hormones and other things(etc drugs) that who can get what percentage of albumin.
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good luck(Y)
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