Mastereven
Forum Newbie
Topics: 3
Posts: 4
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How come ABO HDN only occurs with O mother and A, B, AB child? what if mother is type A and baby is type B? Would baby's red blood cell be lysed by mother's anti-B antibody?
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| match2010
Forum Senior
Topics: 3
Posts: 178
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BECAUSE O mom will transfer her abs thru the placenta ( boold gr O ppl have anti A IgM, anti B IgM, anti AB IgG) .............so IgG ab crosses the placenta and attacks A or B rbc of the child and thats why there is problem in first pregnancy .
you have to know wht blood cells ahve wht type of abs and antigens to solve these kinda q's.....
if mom is type A then wwht type of abs does she have .....figure it out ....and remember only IgG can cross the placenta .....
lemme know if my explaination is wrong ! will recheck
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| taipei817
Forum Newbie
Topics: 1
Posts: 69
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master, yes it would, thats the basis for its protection against Rh problems. (also this ABO HDN not limited to first pregnancy).
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| taipei817
Forum Newbie
Topics: 1
Posts: 69
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sorry , i was wrong. the protection occurs when the baby's blood enter mom and gets destroyed.
but still, ABO HDN would occur whenever there is a difference in blood type between mom and babe, but since it is IgG mediated, instead Ig M, hemolytic effect is usually mild.
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| Mastereven
Forum Newbie
Topics: 3
Posts: 4
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hey thanks guys for the response.
I forgot that only people with blood type O have anti AB IgG antibodies, and IgM doesn't really cross the placenta barrier.
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