GoodGirl
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A,
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| Tiff
Forum Guru
Topics: 54
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He's 35 years old. He most likely has been infected with it at some point in his life since it infects most people without causing disease. So choice C.
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| hottie99
Forum Guru
Topics: 32
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i agree with c, only b/c it's not bacterial, so its not humoral immunity, it's viral which is cell mediated immunity; it's not the others by emlimination, so i agree with C 
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| new_n_lost
Politically InCorrect
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A. Killing of infected cells by the cytotoxic CD8 cells << if you are asking for Primary. Thats how it evades the Tcells.
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| hottie99
Forum Guru
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hmmm i get wat u are saying too new-n-lost.. bc there are no antibodies for cmv rite?? perhaps it is A..
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| GoodGirl
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From eMedicine :
Immunology of CMV infection
In primary infection, CMV immunoglobulin (Ig) M antibodies may be found as early as 4-7 weeks and may persist as long as 16-20 weeks after initial infection. The majority of neutralizing antibody is directed against an envelope glycoprotein gB. Studies have shown that more than 50% of neutralizing activity in convalescent serum is attributable to glycoprotein gB. However, virion tegument proteins such as pp150, pp28, and pp65 evoke strong and durable antibody responses.
Cell-mediated immunity is considered the most important factor in controlling CMV infection. Patients deficient in cell-mediated immunity are at greatest risk for CMV disease. CMV-specific CD4+ and CD8+ lymphocytes play an important role in immune protection after primary infection or reactivation of latent disease. Studies of bone marrow transplant patients have revealed that patients who do not develop CMV-specific CD4+ or CD8+ cells are at higher risk for CMV pneumonitis. Additionally, no cases of CMV pneumonia have been reported in allogeneic marrow transplant patients receiving infusions of CMV-specific CD8+ cells.
http://www.emedicine.com/med/topic504.htm
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| sigh
Forum Elite
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I post this question here because CMV is kind of unusual virus regarding immunology. Correct answer is C.
CMV express "decoy" molecule on cell surface which closely resembles MHC, and NK cells recognize it as "own" and don't kill the infected cell. But "decoy"is still foreign enough to trigger production of ABs. When AB attaches to the "decoy" molecule , NK can lyse the infected cell.
So, this is unigue for this virus and this is new reseach topic.
I did not know about it before so just want to share..
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| new_n_lost
Politically InCorrect
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sigh wrote:
I post this question here because CMV is kind of unusual virus regarding immunology. Correct answer is C.
CMV express "decoy" molecule on cell surface which closely resembles MHC, and NK cells recognize it as "own" and don't kill the infected cell. But "decoy"is still foreign enough to trigger production of ABs. When AB attaches to the "decoy" molecule , NK can lyse the infected cell.
So, this is unigue for this virus and this is new reseach topic.
I did not know about it before so just want to share..
Do you have the explanation or is this one of those where we have scratch the head figure out on our own.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| sigh
Forum Elite
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| | 04/17/08 - 09:51 AM
0 of 1 forum leaders found this post helpful
| #10 |
I am not a teacher here... I post the right answer and I think the explanation is also posted and it looks ok ...To get the better idea go and do research online and read all research papers/experiments results..
Some people just like to think and answer the question why? So, I am just invating these people to think...but do not "scratch" your head dear if it is very hard for you...
I start to feel that you need to clear yourself, step back,take a deep breath, may be get enough sleep, so you can be nice and respectful to others as a moderator supposed to be. Also, I have no idea about existing rule that I should post the question and explanation... I can post just my question if I like. Am I missing something?
Regards
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| myeloma
Forum Junior
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| | 04/17/08 - 10:08 AM
1 of 1 forum leaders found this post helpful
| #11 |
viruses are destroyed by two mechanisms..
1. killed by CTL
2. block host cell protein syntesis..MHC1 which has two effects..one..cells become immune to CTL recognition without MHC1 .That is they escape killing by CTL as CTL cannot recognize foreign antigen if it is not presented with MHC1. second Nk cells kill the cells which lack MHC1 proteins.
now CMV produces a decoy MHC1 whch CTL is unable to recognize so it doesnt kill virus containing cell.But ths decoy MHC1 is sufficient to fool NK cells and thus escapes killing by NK cells as well.
.CMv is then killed by ADCCIgG with specificity for surface expressedCMV antigen.cells used in ADCC are also NK macrophages moncytes esinophils and neutrophils.
this explanation is from kaplan 2008 immunology lecture notes ch 8 CELL MEDIATED EFFECTOR MECHANISM.
and thus my dear friends the answer is C
thank u sigh for bringing it up..i was reading immuno and really liked ths concept and when u posted the question it kinda got refreshed in my mind and i made sure i got it right by checking in LN.hope u guys understood too.
Edited by myeloma on 04/17/08 - 10:16 AM
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| hottie99
Forum Guru
Topics: 32
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dammit so i was rite??? i dont think i should be reading forums with ques so close to my exam, hahaha.. now im starting to waiver with my answers, initially i said C, then i heard out the A arguement, but we're back to C... im just sticking to my guns and not changing answers, i cant afford to!! 
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| GoodGirl
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| | 04/17/08 - 11:46 AM
1 of 1 forum leaders found this post helpful
| #13 |
''Also, I have no idea about existing rule that I should post the question and explanation... I can post just my question if I like. Am I missing something? ''What about the rule of politeness ? I always thought the idea of posting the questions lies in learning from them, not just blindly posting the Q, but also answering and explaining why is the answer correct, others wrong. Also saving the precious time of searching online between thousands of options to find a right article, and bottom line, are you so sure we will be tested on the latest research outcomes ? Must say, I'm really curious where yours Qs are from, is it wrong ? No, it is a human nature. So why should I go online and search myself, when you are one of us here, sharing, learning , helping each other.... so I might just ask you. What is the source of your explanation ?
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| sigh
Forum Elite
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TO GOOD GIRL ONLY:GoodGirl, sweetheart, my last post was adressed to New_lost only... I did wrote the explanation but then n_l came on with very" nice "approach like usually... Read all topic...
I did posted some questions here, difficult questions in my opinion, they are from another forum, explanations also... so, I did post them so somebody can explain it in better way or we can exchange ideas... but looks like not everybody likes it... some people just got mad when they do not have knowledge to answer right...
... go through all topic again...Did I wrote explanation before New and Lost post ?
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| new_n_lost
Politically InCorrect
Topics: 652
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| | 04/17/08 - 03:42 PM
1 of 1 forum leaders found this post helpful
| #15 |
Look Sigh i can say a lot things about your post. But i can t help laughing.
First at the point u said i m no teacher here. Agreed no one is here. But the person who posts the question should have the decency to say or to tell atleast look guys i found this elsewhere answer given is such and if you would like to discuss then i m in for it. You in particular have just started posting questions here and i welcome that with open heart. But keep that in mind i have posted over 3000 questions here, some of which didnt have the answers and i mentioned that in the start of the question. And left room for discussion. People gave their views and we all came to a conclusion.
Second. After Silver said that he/she is not going to discuss this with you. You had a an entire hormonal epiphany and gave a very emotional speech along the lines of :- do we say no to the cancer patient blah blah blah. I asked you a simple question. Do you have the explanation to this question or do we have scratch over heads over it. meaning is it going to be like that thread where we ALL had to search online to find out what was actually going.
For you to take offense on that particular line and give me advice on what i should and shouldnt do. How every thoughtful I do appreciate it. However please dont expect me to be nice when you cant be. By that i mean. You post a question if you dont have an answer then say so. Believe me it doesnt hurt that much to admit that you dont know something. Or You have the answer but arent so very sure about it then please mention it on the top. But if YOU THINK you are satisfied with the answer then please be ready enough to explain ALL THE CHOICES.
Now is that too much to ask.
The only reason i said that comment was that When you ask for a Primary mechanism then CD8 is the answer. ( in my opinion) Cellular Immunity or Cell mediated Immunity is the choice for controlling the infection. If you would have been patient enuf to explain me and OTHERS as to WHY people who Chose A are wrong in this instance. Now that would have been polite on your part but the explanation you provided was bit Oh i had the enlightenment sorry u didnt. ( i know you might have not meant that but it felt that way cos you can see the reaction from GG).
As far as I am concerned If you lack the ability to be humble and forthcoming then you shouldnt expect others to give back the same treatment. There is something called Forum Etiquettes. Maybe you should have a look at it.
Lastly I wasnt trying to be rude or pissed at you for not knowing the answer. I can give you a very detailed explanation that why is Choice A the answer. I dont need to prove anything to anyone especially to you. I have done that already.
All what i needed was the explanation that why A isnt the answer. When you failed at it i said something. If you find that rude or sarcastic then i m saddened to say that wasnt the case. But if you cant handled to be treated in the same way you treat others then you are the one who is naive.
In all honesty i wasnt being rude to you or sarcastic but i guess i hit..................
Cheers and Respects.
PS i have a mom and a gf thanks for caring.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Politically InCorrect
Topics: 652
Posts: 6,096
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Hey Sigh
Do keep posting the Questions just add a disclaimer to it please.
Thanks
Regards
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| sigh
Forum Elite
Topics: 20
Posts: 212
| | 04/17/08 - 04:16 PM
0 of 1 forum leaders found this post helpful
| #17 |
Dear new_n_lost! I did post the explanation for the correct answer. If you can understand why the answer is correct you do not need explanation for others...
I am emotional agree and I am glad I am. That's why I am in medicine. Everybody is different so you are not and I do not care.
You are acting not nicely at all. Notice that it is not only my idea.
You did post a lot of questions here and you did accomplished a lot. Maybe you are ready to take the exam. So do not bother to read my questions...
That's why this forum is so weak. Because moderators like you encourage people not to post...
REGARDS
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| Idlehands
Forum Newbie
Topics: 3
Posts: 52
| | 04/17/08 - 04:35 PM
1 of 1 forum leaders found this post helpful
| #18 |
Dang it
Here is my bit of opinion.
You actually want to know why this forum is becoming weak Because Newbies cant handle their own egos. I will not agree with the Mod most of the time. But in this instance i have to agree with him. For the past 2 yrs certain members cant handle being wrong. Lately its becoming very very hard to ask or to question one's source or method of reasoning.
Look buddy if you cant handle that the other person is smarter than YOU and is a better talker and composer of words than you. Then its not his fault its yours to begin with.
That being said. Can someone tell me why the forum members are simply trying to show that they are better than others. I cant understand this. I have been here for the 2 yrs and i have seen the Forum seniors discussing. They have had longer and more argumentative discussions. But no one took it personally. Why people are being so touchy these days.
It really feels dumb and stupid that if a person asks a question and gets a response this is a new research and you go search on it. Like Hello arent you supposed to help me understand.
I m not smarter than most here ok. So i need to explained more than usual. Myeloma did a good job at it. I liked that post.
But here is the issue the word PRIMARY bugs me . Primary mechanism. So can the poster elaborate on it.
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| hottie99
Forum Guru
Topics: 32
Posts: 619
| | 04/17/08 - 04:42 PM
1 of 1 forum leaders found this post helpful
| #19 |
um, who gives a frick?? this has nothing to do with the question at hand, if u wish to discuss the rules/regulations, why not make a separate post, i saw something new was posted to this question, and i read, and it's lines of this jibberish..
what a waste of time, regardless, glad everyone finds it amusing, but can we get backto the question at hand?? have we come to agreement that it's cell mediated?? 
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| Idlehands
Forum Newbie
Topics: 3
Posts: 52
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sigh wrote:
Dear new_n_lost! I did post the explanation for the correct answer. If you can understand why the answer is correct you do not need explanation for others...
I am emotional agree and I am glad I am. That's why I am in medicine. Everybody is different so you are not and I do not care.
You are acting not nicely at all. Notice that it is not only my idea.
You did post a lot of questions here and you did accomplished a lot. Maybe you are ready to take the exam. So do not bother to read my questions...
That's why this forum is so weak. Because moderators like you encourage people not to post...
REGARDS
Bro I m not going to clarify or justice NNL and his actions but i can say one thing atleast spends time on explaining things to us less smarter people which is not done by rest of the so called smart people. If any question comes up. Jean Robert, GG, Tiff, Bioguyand NNL are usually the ones who post explanations. Macintosh is another one rising up to the occasion. But honestly why dont you have a look around and tell me personally that How many ppl actually bother with explaining things to us. Instead of just looking at posts and simply getting the desired info how many are actually doing a lot to help others. We have ppl who believe that lymphocytes dont proliferate and yet liked to be called smart.
I m sorry if i have missed out any names of ppl who are doing the good work. To Sigh my friend its easier to say that i dont care than to work through your issues.
To NNL mate easy on teh sarcasm you like it rough we know  but stop rubbing it in.
I m not a NNL groupie or in favor of him but wanted to say my mind on it and was hoping it will not cause anymore grievances.
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| Idlehands
Forum Newbie
Topics: 3
Posts: 52
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hottie99 wrote:um, who gives a frick?? this has nothing to do with the question at hand, if u wish to discuss the rules/regulations, why not make a separate post, i saw something new was posted to this question, and i read, and it's lines of this jibberish.. what a waste of time, regardless, glad everyone finds it amusing, but can we get backto the question at hand?? have we come to agreement that it's cell mediated??
Please do tell. Are you refering to my post as the jibberish one. ??
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| sigh
Forum Elite
Topics: 20
Posts: 212
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Hottie is right! It has nothing to do with the question. By the way,I am not consider myself smart ...So, this is waste of time. Thank you everyone. Time to stop.
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| Idlehands
Forum Newbie
Topics: 3
Posts: 52
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sigh wrote:
Hottie is right! It has nothing to do with the question. By the way,I am not consider myself smart ...So, this is waste of time. Thank you everyone. Time to stop.
Hey Thats not fair
You posted a question so can you please be helpful enuf to explain why A is not the correct choice and why NK cells arent considered to be the primary mechanism cos they are the ones killing it.
Can you help here ???
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| Tiff
Forum Guru
Topics: 54
Posts: 561
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The reason why I chose C was because this isn't a first time infection. This man is 35 year olds. Cytomegalovirus is very common and most people are infected, but it doesn't cause disease unless immunocompromised. After having been infected, it would be antibody dependent killing. That was my thought process. Here is a link that I think helps explain.
http://www.pubmedcentral.nih.gov/articlerender.fc...
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| Idlehands
Forum Newbie
Topics: 3
Posts: 52
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Tiff wrote:The reason why I chose C was because this isn't a first time infection. This man is 35 year olds. Cytomegalovirus is very common and most people are infected, but it doesn't cause disease unless immunocompromised. After having been infected, it would be antibody dependent killing. That was my thought process. Here is a link that I think helps explain. http://www.pubmedcentral.nih.gov/articlerender.fc...
First of all.
Thank you very much for responding to my query and posting you resource. It has lately become a very cardinal sin to ask someone or God forbid even suggest someone that they might have to tell us where exactly they read it.
I only read the abstract of the article and it says
"The results indicate that cellular immunity to cytomegalovirus infection includes an antibody-dependent cell-mediated cytotoxicity response which is likely to be highly efficient and may contribute significantly to control of both acute and later stages of infection".
Which does not clearly indicate that this is primary mechanism for eradication of the virus, again leading to my original question. The question asks us what is the primary mechanism. So is this the primary mechanism ??
I will look up things.
Thank you Tiff.
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